Electrophysiological findings of peripheral neuropathy in newly diagnosed type II diabetes mellitus

Journal of the Peripheral Nervous System : JPNS
Eugenia RotaDario Cocito

Abstract

This study was aimed at assessing the electrophysiological signs of peripheral neuropathy in diabetes mellitus (DM) type II patients at diagnosis. Nerve conduction studies (NCS) of median, ulnar, peroneal, tibial and sural nerves were performed in 39 newly diagnosed DM subjects and compared to those of 40 healthy controls. Metabolic indices were also investigated. Electrophysiological alterations were found in 32 (82%) of the DM patients, and more than half of them (62.2%) showed multiple (two to five) abnormal parameters. Because most of the subjects (84.4%) had from two to five nerves involved, these alterations were widespread in the seven nerves evaluated. Forty-two percent of the patients had NCS alterations suggestive of distal median mononeuropathy, implying that metabolic factors in DM make the median nerve more susceptible to focal entrapment. A reduced sensory nerve action potential (SNAP) amplitude was observed in the median nerve in 70% of the patients, in the ulnar in 69% and in the sural nerve only in 22%. In the presence of a decrease in the SNAP amplitude of the ulnar or median nerve, the SNAP amplitude of the sural nerve was normal in 82 or 80% of the subjects, respectively. This finding may be in keeping with ...Continue Reading

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Citations

Dec 10, 2015·The Journal of Sexual Medicine·Biljana MusickiArthur L Burnett
Nov 30, 2011·The Journal of Hand Surgery·Erin Brown, Krista A Genoway
Nov 10, 2009·Journal of Diabetes and Its Complications·Nikolaos Papanas, Dan Ziegler
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Sep 12, 2006·Diabetes Research and Clinical Practice·Eugenia RotaDario Cocito
Aug 15, 2015·Diabetes Research and Clinical Practice·E Rota, D Cocito
Feb 26, 2014·Diabetes Research and Clinical Practice·Eugenia RotaDonata Guidetti
Jul 16, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Chien-Ju YangLi-Chieh Kuo
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