Electrophysiological observations in idiopathic opsoclonus-myoclonus syndrome

Movement Disorders : Official Journal of the Movement Disorder Society
K A Gwinn, John N Caviness

Abstract

To supplement existing knowledge regarding the pathophysiology of the opsoclonus-myoclonus syndrome, electrophysiological findings are reported in three patients with idiopathic opsoclonus-myoclonus. Surface electromyography (EMG) revealed < 100-ms synchronous discharges correlating with the clinical myoclonus. Short duration EMG discharges, with no back-averaged cortical correlate, normal gross electroencephalogram, and no exaggerated responses with either evoked potential testing or long latency EMG responses were observed. The clinical and electrophysiological findings we describe are consistent with a brainstem origin of the myoclonus in this syndrome, with concurrent abnormalities in cerebellar circuits, similar to those described for paraneoplastic cases. The constellation of these electrophysiological findings differentiates the myoclonus in these patients from other clinical myoclonic entities.

References

May 1, 1979·Annals of Neurology·D S Zee, D A Robinson
Jun 1, 1992·Clinical Neuropharmacology·M R Pranzatelli
Apr 1, 1991·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
Dec 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·T HattoriS Kojima
Mar 1, 1985·Brain : a Journal of Neurology·J A ObesoC D Marsden
Mar 1, 1985·Brain : a Journal of Neurology·H ShibasakiR Fukui
Jan 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·J C RothwellC D Marsden
Jan 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·J N CavinessT J McPhee
Dec 1, 1994·Annals of Neurology·A HormigoJ B Posner
Jul 1, 1996·Mayo Clinic Proceedings·J N Caviness

❮ Previous
Next ❯

Citations

Jan 22, 2002·Clinical Neuropharmacology·M R PranzatelliA Wheeler
Sep 17, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·John N Caviness
Mar 6, 2007·Neurophysiologie clinique = Clinical neurophysiology·M Borg
May 13, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Hiroshi SakumaMasayuki Sasaki
Aug 29, 2016·Revue neurologique·E Apartis, L Vercueil
Aug 15, 2017·Brain Sciences·Olaf Eberhardt, Helge Topka
Jan 12, 2021·Movement Disorders Clinical Practice·Malco RossiBart van de Warrenburg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.