Electrophysiological properties of rat retinal Müller (glial) cells in postnatally developing and in pathologically altered retinae

Glia
F FelmyE Guenther

Abstract

Retinal glial Müller cells are characterized by dominant K(+) conductances. The cells may undergo changes of their membrane currents during ontogeny and gliosis as described in rabbit and man. Although the rat retina is often used in physiological experiments, the electrophysiology of rat Müller cells is less well studied. The aim of the present study was to characterize their membrane currents in postnatal development and in two models of retinal degeneration. Freshly isolated cells were subjected to whole-cell patch clamp recordings. During the first 4 weeks after birth of rats, their Müller cells displayed an increase in all membrane currents, particularly in the inward currents elicited at hyperpolarizing potentials. The decrease of the membrane resistance from more than 760 MOmega to less than 50 MOmega was accompanied by a shift of the zero current potential from about -20 mV to -80 mV, similar as earlier observed in developing rabbit Müller cells. These developmental changes were found in pigmented Brown Norway rats as well as in rats with inherited retinal dystrophy (RCS rats). Moreover, an infection of Lewis rats with the Borna disease virus caused substantial neuroretinal degeneration but did not result in a strong re...Continue Reading

References

Jul 16, 1991·Brain Research. Developmental Brain Research·K R FryD M Lam
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Oct 1, 1984·The British Journal of Ophthalmology·P S HiscottD McLeod
Jul 1, 1995·Journal of Neurocytology·W HärtigA Reichenbach
Sep 15, 1994·American Journal of Ophthalmology·G P LewisS K Fisher
Jan 1, 1994·Pflügers Archiv : European journal of physiology·T I ChaoA Reichenbach
Aug 1, 1996·Trends in Neurosciences·E Newman, A Reichenbach
Dec 1, 1996·The European Journal of Neuroscience·M FranckeW Reichelt
Jul 1, 1997·Journal of Neurocytology·T I ChaoA Reichenbach
Oct 7, 1998·Epilepsy Research·A Bordey, H Sontheimer
Aug 24, 1999·The European Journal of Neuroscience·A BringmannA Reichenbach
Feb 9, 2000·Archives of Virology·J KaczaJ Seeger
Apr 14, 2000·Brain Research. Molecular Brain Research·R JabsT H Wheeler-Schilling
Jul 1, 1962·The Journal of Cell Biology·J E DOWLING, R L SIDMAN
May 1, 1965·Comparative Biochemistry and Physiology·S H BISHOP, J W CAMPBELL

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Citations

Aug 13, 2013·Journal of Molecular Neuroscience : MN·Zhongshan ChenZheng Qin Yin
Aug 2, 2013·International Journal of Biological Sciences·Soyeun Park, Yong J Lee
Sep 25, 2002·Journal of Neuroscience Research·Ortrud UckermannAndreas Bringmann
Jun 22, 2011·Progress in Retinal and Eye Research·Antje WurmAndreas Bringmann
Aug 8, 2009·Progress in Retinal and Eye Research·Andreas BringmannAndreas Reichenbach
Jan 26, 2013·The Journal of Comparative Neurology·Jacqueline ChuaMichael Kalloniatis
Jul 28, 2004·Molecular and Cellular Neurosciences·Thomas PannickeAndreas Bringmann
Jul 13, 2004·Neuroscience Letters·Stefan SchopfSerguei N Skatchkov
Sep 13, 2005·Experimental Eye Research·Ianors IandievThomas Pannicke
Sep 10, 2013·Experimental Eye Research·S MétraillerR Roduit
May 19, 2016·Experimental Eye Research·S LassialeC Versaux-Botteri
Oct 19, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Andreas Reichenbach, Andreas Bringmann

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