PMID: 737087Dec 1, 1978Paper

Electrophysiological responses of cerebellum after the administration of diphenylhydantoin (author's transl)

Nō to shinkei = Brain and nerve
H Shimizu

Abstract

Experiments were performed to see the mechanism of anticonvulsive action of Diphenylhydantoin (DPH) especially in relation to the cerebellum. 15 normal adult cats were divided into three groups. After the intravenous administration of 10 mg, 20 mg and 30 mg/kg of DPH in each group, electrophysiological responses of the cerebellum with regard to Purkinje cell action potentials and the cerebellar electrocorticogram were observed for two hours. Purkinje cell action potentials were evaluated in its discharge rates, which were calculated with medical computer. The cerebellar electrocorticogram were analyzed with Fast Fourier Transform method especially in its Adrian rhythm (150--250). It has been demonstrated that Purkinje cell discharge rates increased extremely after a transient suppressed phase, but fast waves of the cerebellar electrocorticogram showed no remarkable changes following the administration of DPH. Plasma DPH concentration went up to a toxic level immediately after DPH injection, but returned to the plateau level after ten to thirty minutes which gradually decreased for two hours. Distribution of DPH was always higher in the cerebellum than in the cerebrum. Recent experimental and clinical studies are suggesting that...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives Internationales De Pharmacodynamie Et De Thérapie
R J Anderson, A Raines
The Journal of Pharmacology and Experimental Therapeutics
D W Shoeman, D L Azarnoff
© 2021 Meta ULC. All rights reserved