Nov 12, 2017

Electrophysiological signatures of spatial boundaries in the human subiculum

BioRxiv : the Preprint Server for Biology
Sang Ah LeeJoshua Jacobs


Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly-related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of the hippocampal formation. While studies of hippocampal function and spatial behavior suggest that similar representations might exist in humans, boundary-related neural activity has not been identified electrophysiologically in humans until now. Here we present direct intracranial recordings from the hippocampal formation of surgical epilepsy patients while they performed a virtual spatial navigation task. Our results suggest that encoding target locations near boundaries elicited stronger theta oscillations than for target locations near the center of the environment and that this difference cannot be explained by variables such as trial length, speed, or movement. These findings provide the first direct evidence of boundary-dependent neural activity localized in humans to the subiculum, the homologue of the hippocampal subregion in in which most boundary cells are found.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Health Center
Spatial Distribution
Entire Entorhinal Cortex
Theta Rhythm
Structure of Hippocampal Formation

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sang Ah LeeJoshua Jacobs
Proceedings of the National Academy of Sciences of the United States of America
Shachar MaidenbaumJoshua Jacobs
BioRxiv : the Preprint Server for Biology
Abhinav GoyalJoshua Jacobs
© 2020 Meta ULC. All rights reserved