Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn

Pain
Anthony H Dickenson, Ann F Sullivan

Abstract

We have studied the effects of intrathecal morphine on the responses of 38 dorsal horn neurones in the intact rat under halothane anaesthesia to A and C fibre electrical stimulation and to natural stimuli applied to their receptive fields. Morphine selectively reduced the C fibre and pinch evoked activity in a dose-dependent naloxone-reversible manner with an ED50 of 7 nmoles. The 'wind-up' of neurones to repetitive stimulation was little altered except with the highest doses (50-150 nmoles) tested. By contrast, the A fibre evoked responses of the neurones were only slightly reduced by morphine and both the tactile responses and receptive field size to innocuous stimuli enhanced for certain cells. The results are discussed in relation to the spinal actions of opiates and their clinical applications.

References

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Citations

Jun 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L Stanfa, A Dickenson
Sep 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y MiwaK Fukushima
Dec 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T KasabaM Takasaki
Nov 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D J KellyS J Brull
Sep 13, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ozgur GunduzAhmet Ulugol
May 27, 1992·European Journal of Pharmacology·E A KalsoA H Dickenson
Apr 29, 1992·European Journal of Pharmacology·A F SullivanA H Dickenson
Sep 1, 1988·Trends in Pharmacological Sciences·C Advokat
Mar 24, 2004·Neuroscience Letters·Elizabeth A Matthews, Anthony H Dickenson
Dec 5, 2003·Trends in Pharmacological Sciences·Xiao-Jun XuZsuzsanna Wiesenfeld-Hallin
Mar 29, 2001·European Journal of Pharmacology·E A Matthews, A H Dickenson
Aug 20, 1997·European Journal of Pharmacology·A DiazA H Dickenson
May 26, 1998·European Journal of Pharmacology·M I GonzalezL Singh
Jan 8, 1999·Peptides·S Martin-SchildJ E Zadina
Mar 8, 2000·Progress in Neurobiology·J F HerreroJ A López-García
May 22, 1998·Neuroscience Letters·G de Araujo LucasZ Wiesenfeld-Hallin
Mar 10, 2001·Journal of Pain and Symptom Management·S Mercadante, R K Portenoy
Apr 12, 2013·Nature Communications·N EijkelkampJ N Wood

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