PMID: 3768680Sep 10, 1986Paper

Electrophysiological study of conditioning lesion effect on rat sciatic nerve regeneration following either prior section or freeze. I. Intensity and time course

Brain Research
M Bondoux-Jahan, A Sebille

Abstract

A peripheral nerve lesion performed distally prior to a proximal axotomy is known to result in an increase in the rate of regeneration of both sensory and motor fibres. This phenomenon is called the 'conditioning lesion effect'. The aim of this study was to determine whether or not the kind of the conditioning lesion influences the intensity and the time course of the conditioning lesion effect. The prior lesion was performed on the tibial nerve of rats at the ankle either by cutting the nerve or freezing it by means of a 1 mm diameter liquid nitrogen cryod. At several points in time up to 28 days a second (or test) lesion consisting of a freeze was performed on the sciatic nerve at the middle part of the thigh. The regeneration of the fastest growing fibres of the sciatic nerve was measured electrophysiologically 5, 7 and 9 days after the test lesion. The nerve was surgically removed, immediately mounted in a recording nerve chamber and stimulated proximally to the test lesion. The distance between the test lesion and the most distal point where an evoked nerve potential was detectable was taken as the regenerated nerve length. Then the rate of regeneration was calculated and the initial delay was estimated by means of a linea...Continue Reading

References

Jun 1, 1971·The Journal of Cell Biology·K M YamadaN K Wessells
Sep 29, 1970·Brain Research·B G Cragg
Jun 13, 1983·Brain Research·J R Sparrow, B Grafstein
Jan 20, 1980·Brain Research·D S FormanD A Fuchs
Jan 1, 1965·Experimental Neurology·S JACOBSON, L GUTH

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Citations

Feb 15, 1995·Journal of Neuroscience Research·C Carobi, O Brunetti
Mar 1, 1993·Journal of Neurobiology·J M Jacob, I G McQuarrie
Jan 1, 1990·Neurosurgical Review·G Brunelli, F Brunelli
Feb 19, 1990·Brain Research·X Navarro, W R Kennedy
Jan 1, 1993·Neuroscience·J P Golding, D A Tonge
May 13, 2014·Cell Transplantation·Wise Young
Mar 15, 2018·Annals of Neurology·Jenna-Lynn B SengerChristine A Webber
Feb 8, 2019·Experimental Neurology·Jenna-Lynn SengerChristine A Webber

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