Electrophysiological study of dorsal column function in streptozocin-induced diabetic rats: comparison with 2,5-hexanedione intoxication

Journal of the Neurological Sciences
M TeradaY Shigeta

Abstract

Dorsal column function and peripheral motor and sensory conduction velocities (MCV, SCV) were evaluated in experimental diabetic rats and compared with those in 2,5-hexanedione (2,5-HD) intoxicated rats. Hyperglycemia was induced by a single injection of streptozocin, and electrophysiological studies were performed 4 and 12 weeks after the injection. For 8 weeks 2,5-HD was administered daily by drinking water to make the 2,5-HD neuropathy rats. Age-matched rats were used as control. In diabetic rats, gracile surface potentials evoked by electrical stimulation of the lumbosacral trunk remained normal during the experimental period, whereas the N and P waves of the evoked potentials were suppressed and the duration of the N wave was prolonged in the 2,5-HD rats. In 4-week diabetic rats, the antidromic compound action potentials of the gracile tract recorded at the most proximal site of lumbosacral trunk were normal. In 12-week diabetic rats, the gracile tract conduction velocity (GTCV) was decreased, although the duration of these potentials was normal. By contrast, the GTCV was decreased and the duration was markedly prolonged in 2,5-HD rats. These findings might indicate that temporal dispersion of incoming volleys in the graci...Continue Reading

References

Aug 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·P S Spencer, H H Schaumburg
Sep 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·B Thiele, E Stålberg
Jan 1, 1970·Brain : a Journal of Neurology·W I McDonald, T A Sears
Apr 1, 1973·Analytical Chemistry·A ZlatkisN Fleischer
Dec 1, 1967·Nihon rinsho. Japanese journal of clinical medicine·Y AbeK Miyai
Nov 1, 1980·Journal of Neuropathology and Experimental Neurology·K SugimuraP J Dyck
Jan 1, 1984·Annals of Neurology·J CraccoE Mark
Jul 1, 1982·Neuropathology and Applied Neurobiology·H B Jones, J B Cavanagh
Jul 1, 1981·Neurology·P R Gupta, L J Dorfman
Feb 1, 1963·Neurology·C L DOLMAN
Jun 1, 1964·Brain : a Journal of Neurology·D GREENBAUMH URICH
Sep 16, 2010·Current Treatment Options in Neurology·Agnes Jani-Acsadi, Robert P Lisak
Mar 15, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ahmet Höke

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Citations

Apr 22, 2004·Neuroscience Research·Hisataka TanakaKazuhiro Ikenaka
Nov 14, 2000·Trends in Neurosciences·W H Gispen, G J Biessels
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tomoya TerashimaLawrence Chan
Oct 30, 2001·Experimental Neurology·J R TonraP S DiStefano
Feb 17, 2005·Neurotoxicology·Richard M LoPachinMaria L Reid
Jun 23, 2004·Toxicology and Applied Pharmacology·Richard M LoPachinLisa A Opanashuk
Aug 4, 2004·Toxicology and Applied Pharmacology·Richard M LoPachin, Anthony P DeCaprio

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