PMID: 18478943May 16, 2008

Electrophysiological study of symptomatic improvement by subthalamic stimulation on patients with Parkinson's disease

Zhonghua yi xue za zhi
Shan TianYongjie Li

Abstract

To investigate the correlation of the neuronal activity in the subthalamic nucleus (STN), active contacts of deep brain stimulation (DBS), and clinical outcome of Parkinson's disease (PD). Nineteen patients with PD, 12 males and 17 females, aged (61 +/- 8), received STN DBS. Simultaneously microelectrode recording was performed in the STN and electromyography (EMG) was conducted on the selected muscles of contralateral limb during the surgery. Single unit analysis and cross-correlation test were carried out to study the neuronal pattern-related parkinsonian symptoms. All patients were evaluated with the unified Parkinson's disease rating scale (UPDRS) in "off" state pre- and post-operatively. Two hundred and seventy-eight STN neurons were identified in 29 trajectories. Among these neurons, 35 (12.6%) fired at the same frequency as the tremor (R = 0.7, P < 0.01) and was defined as "tremor cell"; 91 (32.7%) fired rapid tonic discharge, and 152 (54.7%) fired irregular neuronal discharge. Majority of the tremor cells (74.3%, 26/35) were localized at the dorsal part of STN, while majority of the tonic discharge cells (59.3%, 54/94) and irregular discharge cells (65.1%, 99/152) were distributed in the ventral part of STN were localiz...Continue Reading

Related Concepts

Electrophysiology (Science)
Microelectrodes
Parkinson Disease
Structure of Subthalamic Nucleus
Electrical Stimulation of the Brain
Electromyography
Limb Structure
Muscle
Neurons
Patient Discharge

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