PMID: 9426301Feb 28, 1998Paper

Electrophysiological study on the high K+ sensitivity of rat glomerulosa cells

Pflügers Archiv : European journal of physiology
Péter VárnaiA Spät

Abstract

Elevation of extracellular potassium concentration by as little as some tenth of mM activates rat adrenal glomerulosa cells. In the present study some factors responsible for this high K+ sensitivity were examined. Using whole-cell voltage-clamp technique we found that both T-type and L-type voltage-dependent Ca2+ channels have very low threshold potential (-71 and -58 mV, resp.). By means of patch-clamp technique combined with single-cell fluorimetry we also provided evidence that the activation of Igl, a K+-activated inward rectifying current is associated with Ca2+ influx. Both the low activation threshold of voltage-dependent Ca2+ channels and the function of Igl contribute to the exceptional K+ sensitivity of the glomerulosa cells.

Citations

Mar 8, 2012·Pflügers Archiv : European journal of physiology·András Spät, Gergö Szanda
May 12, 2004·Molecular and Cellular Endocrinology·András Spät
Mar 18, 2004·Molecular and Cellular Endocrinology·András Spät, János G Pitter
Jan 8, 2000·Clinical and Experimental Pharmacology & Physiology·J F Tait, S A Tait
May 5, 1999·Fundamental & Clinical Pharmacology·C J KenyonR Fraser
Apr 10, 2013·European Journal of Endocrinology·Felix Beuschlein
Mar 15, 2016·Frontiers in Endocrinology·András SpätGergő Szanda
Nov 24, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Victor N UebeleThomas M Connolly
Jan 24, 2009·Biochimica Et Biophysica Acta·Thomas E Gunter, Shey-Shing Sheu
Mar 27, 2004·Physiological Reviews·András Spät, László Hunyady
Sep 10, 2003·Endocrinology·Judit K MakaraAndrás Spät
Jul 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Marcel D PayetNicole Gallo-Payet
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·T KigoshiK Uchida
Jan 15, 1999·Endocrine Research·G P VinsonJ R Puddefoot

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