Abstract
Characterizing the cellular targets of kHz (1-10 kHz) electrical stimulation remains a pressing topic in neuromodulation because expanding interest in clinical application of kHz stimulation has surpassed mechanistic understanding. The presumed cellular targets of brain stimulation do not respond to kHz frequencies according to conventional electrophysiology theory. Specifically, the low-pass characteristics of cell membranes are predicted to render kHz stimulation inert, especially given the use of limited-duty-cycle biphasic pulses. Precisely because kHz frequencies are considered supra-physiological, conventional instruments designed for neurophysiological studies such as stimulators, amplifiers and recording microelectrodes do not operate reliably at these high rates. Moreover, for pulsed waveforms, the signal frequency content is well above the pulse repetition rate. Thus, the very tools used to characterize the effects of kHz electrical stimulation may themselves be confounding factors. We illustrate custom equipment design that supports reliable electrophysiological recording during kHz-rate stimulation. Given the increased importance of kHz stimulation in clinical domains and compelling possibilities that mechanisms of ...Continue Reading
References
Dec 1, 1996·Trends in Neurosciences·J MagistrettiE Wanke
Aug 22, 2001·Journal of Neuroscience Methods·D T O'KeeffeC A Byrne
Jun 12, 2004·Medical & Biological Engineering & Computing·K L Kilgore, N Bhadra
Jan 22, 2005·Journal of Neuroscience Methods·Daniel R MerrillJohn G R Jefferys
Dec 20, 2008·Physical Therapy·Alex R Ward
Jan 3, 2009·Experimental Neurology·Svjetlana MiocinovicCameron C McIntyre
May 14, 2014·Journal of Neuroscience Methods·Manfred FrankeKevin Kilgore
Dec 31, 2014·PLoS Biology·Randolph F HelfrichAndreas K Engel
Sep 8, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Zhiyang SongBengt Linderoth
Apr 12, 2016·Frontiers in Human Neuroscience·James Dowsett, Christoph S Herrmann
Oct 21, 2016·Journal of Neurophysiology·Nathan D CrosbyWarren M Grill
Nov 27, 2016·NeuroImage·Toralf NeulingGianpaolo Demarchi
Apr 1, 2017·Journal of Neural Engineering·N A PelotW M Grill
Jun 3, 2017·Cell·Nir GrossmanEdward S Boyden
Jun 3, 2017·Cell·Jacek Dmochowski, Marom Bikson
Nov 21, 2017·NeuroImage·Nima Noury, Markus Siegel
Nov 23, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Shiying LiRobert D Foreman
Dec 9, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Simon J ThomsonMichael Moffitt
Jan 1, 2018·Brain Stimulation·L Stephen LesperanceSteven A Prescott
Jan 20, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Selaiman Noori, Neel Mehta
Feb 9, 2018·Journal of Neural Engineering·Yogi A Patel, Robert J Butera
Feb 11, 2018·NeuroImage·Ehsan NegahbaniFlavio Fröhlich
Jun 4, 2018·NeuroImage·Florian H KastenChristoph S Herrmann
Oct 16, 2018·NeuroImage·Nigel GebodhMarom Bikson
Nov 30, 2018·Brain Stimulation·Adantchede L ZannouMarom Bikson