Electropolymerized molecularly imprinted polypyrrole film for sensing of clofibric acid

Sensors
Bianca SchweigerMathias Ulbricht

Abstract

Piezoelectric quartz crystals and analogous gold substrates were electrochemically coated with molecularly imprinted polypyrrole films for pulsed amperometric detection (PAD) of clofibric acid, a metabolite of clofibrate. Cyclic voltammetry data obtained during polymerization and deposited weight estimations revealed a decrease of the polymerization rate with increasing clofibric acid concentration. XPS measurements indicated that clofibric acid could be removed after imprinting with an aqueous ethanol solution, which was further optimized by using PAD. Zeta potential and contact angle measurements revealed differences between molecularly imprinted (MIP) and non-imprinted polymer (NIP) layers. Binding experiments with clofibric acid and other substances showed a pronounced selectivity of the MIP for clofibric acid vs. carbamazepine, but the response of MIP and NIP to 2,4-dichlorophenoxyacetic acid was higher than that for clofibric acid. A smooth surface, revealed by AFM measurements, with roughness of 6-8 nm for imprinted and non-imprinted layers, might be a reason for an excessively low density of specific binding sites for clofibric acid. Furthermore, the decreased polymerization rate in the presence of clofibric acid might ...Continue Reading

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Citations

Jun 13, 2019·Scientific Reports·Milena ŠetkaStella Vallejos
Mar 5, 2021·Biosensors & Bioelectronics·A HammoudM Sawan

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Methods Mentioned

BETA
biosensors
solid phase extraction
X-ray
atomic force microscopy
delamination
AFM

Software Mentioned

DeltaPsi2
GPES

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