Oct 1, 1989

Electroretinograms to checkerboard pattern reversal in cats: physiological characteristics and effect of retrograde degeneration of ganglion cells

Electroencephalography and Clinical Neurophysiology
S TobimatsuM Gujrati

Abstract

Pattern electroretinograms (P-ERGs) evoked by alternating checks were studied in cats. Spatial frequency functions for transient and steady-state P-ERG waves showed a bimodal distribution with a preferred frequency at 0.6-0.75 c/deg and a second amplitude increase at frequencies lower than 0.5 c/deg. Decreasing the pattern luminance by 0.5 log units produced a shift of the spatial tuning curve toward lower spatial frequencies. No temporal tuning was noted in the temporal frequency functions. The bimodal distribution suggests that at spatial frequencies higher than 0.5 c/deg, the tuning reflects a 'contrast response' originating in cells with center surround organization. At spatial frequencies below 0.5 c/deg, the 'luminance response' becomes predominant and is generated in cells sensitive to mean luminance changes. Transient and steady-state P-ERGs to medium and high spatial frequencies were abolished by section of the optic nerve, while low spatial frequency stimuli at or below 0.3 c/deg continued to evoke P-ERGs at 1, 5 and 10 months after surgery. Quantitative whole mount retina microscopic examination confirmed the retrograde degeneration of the ganglion cells. It is concluded that both transient and steady-state P-ERGs to...Continue Reading

  • References31
  • Citations17

Citations

Mentioned in this Paper

Entire Optic Nerve
Ganglion Cell
Entire Retina
Reaction Time
Electroretinography
Nerve Degeneration
Retrograde Degeneration
Retinal Diseases
Visual Evoked Cortical Potential
Malignant Neoplasm of Retina

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