Electrospinning chitosan/poly(ethylene oxide) solutions with essential oils: Correlating solution rheology to nanofiber formation.

Carbohydrate Polymers
Katrina A RiegerJessica D Schiffman

Abstract

Electrospinning hydrophilic nanofiber mats that deliver hydrophobic agents would enable the development of new therapeutic wound dressings. However, the correlation between precursor solution properties and nanofiber morphology for polymer solutions electrospun with or without hydrophobic oils has not yet been demonstrated. Here, cinnamaldehyde (CIN) and hydrocinnamic alcohol (H-CIN) were electrospun in chitosan (CS)/poly(ethylene oxide) (PEO) nanofiber mats as a function of CS molecular weight and degree of acetylation (DA). Viscosity stress sweeps determined how the oils affected solution viscosity and chain entanglement (Ce) concentration. Experimentally, the maximum polymer:oil mass ratio electrospun was 1:3 and 1:6 for CS/PEO:CIN and:H-CIN, respectively; a higher chitosan DA increased the incorporation of H-CIN only. The correlations determined for electrospinning plant-derived oils could potentially be applied to other hydrophobic molecules, thus broadening the delivery of therapeutics from electrospun nanofiber mats.

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Citations

Oct 30, 2016·International Journal of Molecular Sciences·Solomon Mengistu LemmaMarguerite Rinaudo
May 5, 2017·Journal of Food Science·Zhi-Cheng YaoJing-Song Li
Feb 23, 2018·International Journal of Molecular Sciences·Fei LiuFang Zhong
Mar 25, 2017·Nanomaterials·Wanwei ZhangElisa Mele
Jul 28, 2017·Food Science & Nutrition·Mounia ArkounAbdellah Ajji
Apr 4, 2021·Polymers·Christian Enrique Garcia GarciaMarguerite Rinaudo
Sep 17, 2020·Environmental Science & Technology·Juejing LiuWei-Hong Zhong

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