Electrospinning of Highly Aligned Fibers for Drug Delivery Applications

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Mohammadjavad EslamianMohammad Reza Abidian

Abstract

Electrospinning is a straightforward, cost-effective, and versatile technique for fabrication of polymeric micro/nanofibers with tunable structural properties. Controlling the size, shape, and spatial orientation of the electrospun fibers is crucial for utilization in drug delivery and tissue engineering applications. In this study, for the first time, we systematically investigate the effect of processing parameters, including voltage, syringe needle gauge, angular velocity of rotating wheel, syringe-collector distance, and flow rate on the size and alignment of electrospun PLGA fibers. Optimizing these parameters enabled us to produce highly aligned and monodisperse PLGA fibers (spatial orientation> 99% and coefficient of variation< 0.5). To assess the effect of fiber alignment on the release of encapsulated drugs from these fibers, we incorporated dexamethasone, an anti-inflammatory drug, within highly-aligned and randomly-oriented fibers with comparable diameters (~0.87 μm) and compared their release profiles. In-vitro release studies revealed that the aligned fibers had less burst release (~10.8% in 24 hr) and more sustained release (~8.8% average rate of change for 24 days) compared to the random fibers. Finally, the degr...Continue Reading

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Citations

May 28, 2020·Tissue Engineering. Part C, Methods·Xiaolian NiuWeiyi Chen
Oct 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tzu-Cheng SungQingsong Ye
Nov 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eliseu A MünchowMarco C Bottino
Mar 31, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andrea LuraghiLorenzo Moroni
May 25, 2021·ACS Applied Materials & Interfaces·Kyunghee KimDarrin J Pochan
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kiran R AdhikariVinoy Thomas

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Methods Mentioned

BETA
confocal microscopy
scanning electron microscopy

Software Mentioned

Origin
Image J
ConfoMap

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