Electrospinning of hyaluronan/polyvinyl alcohol in presence of in-situ silver nanoparticles: Preparation and characterization

International Journal of Biological Macromolecules
A M Abdel-MohsenJ Jancar

Abstract

Novel nanofibers mats were fabricated by electrospinning of polyvinyl alcohol/hyaluronan (PVA/HA) solutions in the presence of silver nanoparticles (AgNPs). The AgNPs were synthesized by in-situ chemical reduction of silver ions (Ag+) using HA as a reducing and stabilizing agent. Narrow size distribution and spherical shape of AgNPs were achieved by optimizing the initial silver nitrate concentration (0.01 to 1 M) and reaction time (10-60 min). HA-AgNPs nanocomposite and PVA/HA-AgNPs nanofibrous mats were fabricated by electrospinning technique from aqueous solution containing a different mass ratio of PVA and HA-AgNPs and characterized by UV/Vis spectroscopy, SEM, TEM, DLS, XRD, TGA, and ATR-FTIR. Mechanical and rheological properties were also investigated and discussed. The novel nanofibrous mats show great potential in skin regeneration and drug carrier applications.

Citations

Oct 1, 2020·Journal of Drug Targeting·Zaynab Sadeghi-GhadiAli Nokhodchi
Jan 22, 2021·International Journal of Biological Macromolecules·Karine Cappuccio CastroLucia Helena Innocentini Mei
Jun 14, 2020·Carbohydrate Polymers·Maha M AbdallahMaria do Rosário Bronze
Aug 7, 2021·International Journal of Biological Macromolecules·Elbadawy A KamounEl-Refaie S Kenawy

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