Electrospinning of thermoplastic carboxymethyl cellulose/poly(ethylene oxide) nanofibers for use in drug-release systems

Materials Science & Engineering. C, Materials for Biological Applications
Akbar Esmaeili, Mahsa Haseli

Abstract

Polymeric delivery systems using electrospun nanofibers have been developed for many applications, notably for drug delivery and tissue engineering in the healthcare industry. In this study, a nanofiber drug carrier was fabricated via two different electrospinning processes, blend and coaxial, using a new degradable thermoplastic carboxymethyl cellulose (TCMC) and poly(ethylene oxide) (PEO). The TCMC was synthesized by graft copolymerization with methyl acrylate. Tetracycline hydrochloride served as a drug model incorporated within these nanofibers and their performance as a drug-carrier scaffold was evaluated. The structure morphology of the obtained nanofibers was viewed under scanning electron microscope, and the changes of the structural of polymer before and after graft and confirmation of incorporation of the drug on the fibers was characterized by Fourier transform infrared spectroscopy. Response surface methodology was applied to predict the optimum condition for fabrication of the nanofibers. The drug-delivery profile showed that drug release from the optimized core-shell sample TCMC 3% (w/v)/PEO 1% (w/v) was much slower than for the blend nanofibers and was sustained for 72h with only 26.06% burst release within the f...Continue Reading

Citations

Jun 21, 2018·Advanced Healthcare Materials·Juanjuan LiXingyu Jiang
Nov 17, 2017·Journal of Biomedical Materials Research. Part a·Akbar Esmaeili, Meisam Khodaei
Jun 16, 2018·RSC Advances·Kokkarachedu VaraprasadPatricio Oyarzun
Sep 5, 2018·Carbohydrate Polymers·J G Durán-GuerreroJavier Rivera De La Rosa
Jan 20, 2021·ACS Biomaterials Science & Engineering·Meisam Khodaei, Akbar Esmaeili

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