Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations

Carbohydrate Polymers
María Alejandra MorenoMaría Inés Isla

Abstract

The design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the ex...Continue Reading

Citations

Oct 12, 2020·Journal of Cosmetic Dermatology·María Eugenia OrquedaMaría Inés Isla
Dec 19, 2020·International Journal of Biological Macromolecules·Sheersha Pramanik, Vaishnavi Sali
Feb 4, 2021·Nanomaterials·Giulia ChindamoMarina Gallarate
Mar 27, 2021·Carbohydrate Polymers·Victor Hugo Sousa AraujoMarlus Chorilli
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yijie HuaChanghu Xue

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