Electrosprayed microparticles for intestinal delivery of prednisolone

Journal of the Royal Society, Interface
T ShamsM Edirisinghe

Abstract

Single and coaxial electrospraying was used to prepare Eudragit L100-55 polymer microparticles containing prednisolone as the active pharmaceutical ingredient. Different compositions of prednisolone and Eudragit L100-55 were used to develop five different formulations with different polymer : drug ratios. The resultant microparticles had a toroidal shape with a narrow size distribution. Prednisolone was present in an amorphous physical state, as confirmed by X-ray diffraction analysis. Dissolution studies were carried out in order to investigate the feasibility of the proposed system for site-specific release of prednisolone. The release rates were interpreted in terms of diffusion-controlled release. It was shown that utilization of pH-responsive Eudragit L100-55 could minimize the release of prednisolone in the acidic conditions of the stomach, which was followed by rapid release as the pH of the release medium was adjusted to 6.8 after the first 2 h. This is especially desirable for the treatment of conditions including inflammatory bowel disease and colon cancer.

References

Jan 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rosalía RodríguezAngel Concheiro
Mar 28, 2007·Journal of Pharmaceutical Sciences·M VogtD M Barends
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Richard A KendallAbdul W Basit
Oct 16, 2009·Journal of the Royal Society, Interface·Marjan EnayatiMohan Edirisinghe
Sep 23, 2010·Organic & Biomolecular Chemistry·Eliška BílkováLudvík Beneš
Mar 15, 2011·Molecular Pharmaceutics·Shaoling ZhangShinji Sakuma
Mar 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mohamed A AlhnanAbdul W Basit
Nov 15, 2011·Current Pharmaceutical Design·Eliska BílkováMilos Sedlák
Apr 27, 2012·Journal of the Royal Society, Interface·Adam BohrEleanor Stride
Mar 30, 2013·Colloids and Surfaces. B, Biointerfaces·Shilei HaoTingwang Guo
May 11, 2013·Journal of Advanced Pharmaceutical Technology & Research·Rohit MehtaPravin Pawar
Sep 27, 2013·Journal of the Royal Society, Interface·Sheyda LabbafJennifer L Rohn
Nov 22, 2013·Journal of Pharmaceutical Sciences·Upulitha Eranka IllangakoonNicholas P Chatterton
Jan 1, 2011·Pregnancy Hypertension·Carl A HubelIan P Crocker
May 22, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Megdi EltayebAnthony Harker

❮ Previous
Next ❯

Citations

Jan 19, 2020·Journal of Functional Biomaterials·Alan Í S MoraisAnderson O Lobo
Mar 12, 2021·Advances in Colloid and Interface Science·Hadis RostamabadiSeid Mahdi Jafari
Jan 6, 2022·Journal of Microencapsulation·Nadia Andrade AleixoFlávia Aparecida Resende

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy
X-ray

Software Mentioned

FreeFEM
ImageJ

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.