Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering

Biomaterials
Yanzhong ZhangChwee Teck Lim

Abstract

The development of bioinspired or biomimetic materials is essential and has formed one of the most important paradigms in today's tissue engineering research. This paper reports a novel biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan (HAp/CTS) prepared by combining an in situ co-precipitation synthesis approach with an electrospinning process. A model HAp/CTS nanocomposite with the HAp mass ratio of 30 wt% was synthesized through the co-precipitation method so as to attain homogenous dispersion of the spindle-shaped HAp nanoparticles (ca. 100 x 30 nm) within the chitosan matrix. By using a small amount (10 wt%) of ultrahigh molecular weight poly(ethylene oxide) (UHMWPEO) as a fiber-forming facilitating additive, continuous HAp/CTS nanofibers with a diameters of 214+/-25 nm had been produced successfully and the HAp nanoparticles with some aggregations were incorporated into the electrospun nanofibers. Further SAED and XRD analysis confirmed that the crystalline nature of HAp remains and had survived the acetic acid-dominant solvent system. Biological in vitro cell culture with human fetal osteoblast (hFOB) cells for up to 15 days demonstrated that the incorporation of HAp nanoparticles into chitosan nanofibrous s...Continue Reading

References

Oct 6, 1986·FEBS Letters·S Weiner, W Traub
Jan 1, 1995·Sheng li ke xue jin zhan [Progress in physiology]·X T Pei
Apr 21, 1995·The Journal of Biological Chemistry·C M StanfordR J Midura
Jul 29, 1998·Medical Engineering & Physics·J Y RhoP Zioupos
Nov 15, 2003·Biomaterials·Hyoung-Joon JinDavid L Kaplan
Mar 4, 2005·Journal of Materials Science. Materials in Medicine·Zhang LiZhang Xiang
Apr 30, 2005·Biomaterials·Xinying GengJinho Jang
May 12, 2005·Biomaterials·Narayan BhattaraiMiqin Zhang
Feb 7, 2006·Biomaterials·Chunmei LiDavid L Kaplan
Feb 6, 2007·Journal of Biomaterials Science. Polymer Edition·Xu-Liang DengXiao-Ping Yang
Feb 14, 2007·Journal of Biomedical Materials Research. Part a·Gang SuiSeungkon Ryu
May 7, 2008·Biomedical Materials·S A CatledgeY K Vohra

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Citations

Mar 17, 2010·Journal of Materials Science. Materials in Medicine·Nguyen Thi Hiep, Byong-Taek Lee
Jun 18, 2011·Journal of Materials Science. Materials in Medicine·Lihong LaoChangyou Gao
Nov 16, 2011·Journal of Materials Science. Materials in Medicine·Junjun FanGuoxian Pei
Dec 7, 2011·Journal of Materials Science. Materials in Medicine·Lingli LiKaihui Nan
May 4, 2012·Journal of Materials Science. Materials in Medicine·Ganesh NityaShantikumar V Nair
Mar 15, 2011·Musculoskeletal Surgery·Alberto Di MartinoVincenzo Denaro
Apr 10, 2013·Journal of Biomaterials Science. Polymer Edition·Radhakrishnan SridharSeeram Ramakrishna
Jan 8, 2011·Tissue Engineering. Part B, Reviews·Jong Kyu Hong, Sundararajan V Madihally
Mar 23, 2011·Journal of Biomaterials Science. Polymer Edition·Yan SuSeeram Ramakrishn
Aug 28, 2012·International Journal of Nanomedicine·Fernanda M P TonelliRodrigo R Resende
Feb 27, 2014·International Journal of Nanomedicine·Jennifer Sims-MourtadaEric B Kmiec
Feb 9, 2012·International Journal of Molecular Sciences·Chiara GardinBarbara Zavan
Oct 16, 2010·Marine Drugs·Jayachandran Venkatesan, Se-Kwon Kim
Jul 16, 2013·Acta Biomaterialia·Tao JiangCato T Laurencin
Jan 25, 2014·Journal of Materials Science. Materials in Medicine·Izabella RajzerWojciech Chrzanowski
Jul 8, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sheeny Lan Levengood, Miqin Zhang
Dec 1, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Er-Yuan ChuangHsing-Wen Sung
Mar 9, 2012·Bioinorganic Chemistry and Applications·Michele IafiscoNorberto Roveri
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Dmitry ZaytsevPeter Panfilov
Aug 6, 2014·Journal of Materials Science. Materials in Medicine·A SusluU Cocen
Apr 24, 2009·Annals of Plastic Surgery·Courtney R ReedJohn A van Aalst
Mar 24, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·J VenugopalS Ramakrishna
Jun 27, 2015·Journal of Biomedical Materials Research. Part a·Shahrzad FathollahipourMojtaba Koosha
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Feb 27, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Nina LiaoCheol Sang Kim
Mar 8, 2013·Journal of Biomedical Materials Research. Part a·Arie BruininkKatharina Maniura-Weber
Mar 19, 2013·Materials Science & Engineering. C, Materials for Biological Applications·A K JaiswalJ R Bellare

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