Electrospun core-shell structured nanofilm as a novel colon-specific delivery system for protein

Carbohydrate Polymers
Peng WenHong Wu

Abstract

A novel core-shell structured nanofilm for the delivery of protein to the colon was developed by coaxial electrospinning using bovine serum albumin (BSA) as protein model. Firstly, the BSA-loaded chitosan nanoparticle was prepared by ionic gelation, and then the coaxial nanofilm was fabricated using alginate as shell layer and the BSA-loaded chitosan nanoparticle as core layer. Scanning electron microscopy analysis showed that the obtained nanofilm exhibited a smooth surface, and the core-shell structure was evidenced by the aid of transmission electron microscopy. There was little change in the secondary structure of encapsulated BSA and around 75% of BSA was released in the simulated colonic fluid. The corresponding kinetics models of BSA release in different simulated digestive fluids were built and the results revealed that the release of BSA in colon followed a complex mechanism. This study shows that electrospun nanofilm is a promising colon-specific delivery system for bioactive protein.

Citations

May 24, 2017·Journal of Agricultural and Food Chemistry·Peng WenHong Wu
Oct 5, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Hao ChengGangliang Huang
Jul 25, 2020·Advanced Drug Delivery Reviews·Samad AhadianAli Khademhosseini
Mar 23, 2021·Critical Reviews in Food Science and Nutrition·Yun-Shan WeiHong Wu
Apr 10, 2021·Journal of Biomedical Materials Research. Part a·Neelima AnupRakesh K Tekade
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei HaYan-Ping Shi
Sep 28, 2017·Journal of Agricultural and Food Chemistry·Peng WenHong Wu
Sep 28, 2018·Journal of Agricultural and Food Chemistry·Kun FengHong Wu

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