Electrospun eri silk fibroin scaffold coated with hydroxyapatite for bone tissue engineering applications

Progress in Biomaterials
Muthumanickkam AndiappanPramanik Krishna

Abstract

Natural biomaterials such as collagen, silk fibroin, and chitosan, and synthetic biopolymers such as polylactic acid, polycaprolactone, polyglycolic acid, and their copolymers are being used as scaffold for tissue engineering applications. In the present work, a fibrous mat was electrospun from eri silk fibroin (ESF). A composite of hydroxyapatite (Hap) and the ESF scaffold was prepared by soaking the ESF scaffold in a solution of calcium chloride and then in sodium diammonium phosphate. The average tensile stress of the pure ESF and hydroxyapatite-coated ESF scaffold (ESF-Hap) was found to be 1.84 and 0.378 MPa, respectively. Pure ESF and ESF-Hap scaffolds were evaluated for their characteristics by a themogravimetric analyzer and Fourier transform infrared spectroscope. The crystallinity and thermal stability of the ESF-Hap scaffold were found to be more than that of uncoated eri silk nanofiber scaffold. The water uptake of the pure ESF and ESF-Hap scaffolds was found to be 69% and 340%, respectively, in distilled water as well as phosphate buffer saline. The hemolysis percentage of both scaffolds was less than 5%, which indicate their good blood compatibility. The cytocompatibility studied by 3-(4,5-dimethyl) thiazol-2-yl-2,...Continue Reading

References

Nov 22, 1997·Journal of Biomedical Materials Research·M MarcolongoW C LaCourse
Mar 29, 2000·Journal of Biomedical Materials Research·T FuruzonoY Tamada
Apr 11, 2000·Journal of Biomedical Materials Research·C DuK de Groot
Nov 9, 2002·Biomaterials·Gregory H AltmanDavid L Kaplan
Aug 5, 2003·Biomaterials·Bruce PanilaitisDavid L Kaplan
Jun 23, 2004·Biomaterials·Lorenz MeinelDavid L Kaplan
Sep 13, 2005·Cell Biology International·J VenugopalS Ramakrishna
Oct 20, 2005·Journal of Bioscience and Bioengineering·Yoshihiro ItoOh Hyeong Kwon
May 19, 2009·Acta Biomaterialia·Molamma P PrabhakaranS Ramakrishna

❮ Previous
Next ❯

Citations

Nov 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Boguslawa ŻywickaZbigniew Rybak
Feb 13, 2018·European Biophysics Journal : EBJ·Mehdi AmirikiaMalek Soleimani Mehranjani
Apr 17, 2020·Journal of Biomedical Materials Research. Part a·Valarmathi NarayananArunai Nambi Raj Narayanasamy
Sep 12, 2015·Journal of Tissue Engineering and Regenerative Medicine·Andra SujanaSeeram Ramakrishna
Sep 2, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Niladri Nath PandaSriramakamal Jonnalagadda
Sep 30, 2015·BioMed Research International·Meng-Liu YuHui-Ming Wang
Apr 24, 2019·Journal of Materials Science. Materials in Medicine·Ajinkya A ShitoleBaijayantimala Garnaik
Nov 14, 2015·Progress in Biomaterials·Wafa I Abdel-FattahGhareib W Ali

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
biopsy
profileration

Software Mentioned

Fityk

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.