Electrospun matrices for localised controlled drug delivery: release of tetracycline hydrochloride from layers of polycaprolactone and poly(ethylene-co-vinyl acetate)

Drug Delivery and Translational Research
Nour AlhuseinPaul A De Bank

Abstract

We report the controlled release of tetracycline (Tet) HCl from a three-layered electrospun matrix for the first time. Five formulations of electrospun poly-ε-caprolactone (PCL) and poly(ethylene-co-vinyl acetate) (PEVA) have been designed, prepared as micro/nanofibre layers, and assayed for the controlled release of the clinically useful antibiotic Tet HCl with potential applications in wound healing and especially in complicated skin and skin-structure infections. Tet HCl was also chosen as a model drug possessing a good ultraviolet (UV) chromophore and capable of fluorescence together with limited stability. Tet HCl was successfully incorporated (essentially quantitatively at 3 %, w/w) and provided controlled release from multilayered electrospun matrices. The Tet HCl release test was carried out by a total immersion method on 2 × 2 cm(2) electrospun fibrous mats in Tris or phosphate-buffered saline heated to 37 °C. The formulation PCL/PEVA/PCL with Tet HCl in each layer gave a large initial (burst) release followed by a sustained release. Adding a third layer to the two-layered formulations led to release being sustained from 6 days to more than 15 days. There was no detectable loss of Tet chemical stability (as shown by UV...Continue Reading

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Citations

Dec 1, 2013·Drug Delivery and Translational Research·Nour AlhuseinPaul A De Bank
Jun 9, 2015·Journal of Pharmaceutical Sciences·Young Ju SonHyuk Sang Yoo
Mar 30, 2016·Colloids and Surfaces. B, Biointerfaces·Said Mahmoud AhmedJinyi Wang
Jun 14, 2016·Colloids and Surfaces. B, Biointerfaces·Baolin WangJing-Song Li
Jan 1, 2016·Nanomaterials·Bogdanel Silvestru MunteanuCornelia Vasile
Dec 28, 2018·Pharmaceutics·Rajan Sharma BhattaraiSarit Bhaduri

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