Electrospun Nanofibers as Carriers of Microorganisms, Stem Cells, Proteins, and Nucleic Acids in Therapeutic and Other Applications

Frontiers in Bioengineering and Biotechnology
Spase Stojanov, Aleš Berlec

Abstract

Electrospinning is a technique that uses polymer solutions and strong electric fields to produce nano-sized fibers that have wide-ranging applications. We present here an overview of the use of electrospinning to incorporate biological products into nanofibers, including microorganisms, cells, proteins, and nucleic acids. Although the conditions used during electrospinning limit the already problematic viability/stability of such biological products, their effective incorporation into nanofibers has been shown to be feasible. Synthetic polymers have been more frequently applied to make nanofibers than natural polymers. Polymer blends are commonly used to achieve favorable physical properties of nanofibers. The majority of nanofibers that contain biological product have been designed for therapeutic applications. The incorporation of these biological products into nanofibers can promote their stability or viability, and also allow their delivery to a desired tissue or organ. Other applications include plant protection in agriculture, fermentation in the food industry, biocatalytic environmental remediation, and biosensing. Live cells that have been incorporated into nanofibers include bacteria and fungi. Nanofibers have served a...Continue Reading

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Citations

Oct 8, 2020·Biomaterials Science·Kübra Kaygisiz, Christopher V Synatschke
Jan 8, 2021·Soft Matter·Laura K Rivera-TarazonaTaylor H Ware
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Methods Mentioned

BETA
biosensors
Biosensing
biosensor
environmental stress
transfection
PCL

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