Electrospun nanostructured chitosan-poly(vinyl alcohol) scaffolds: a biomimetic extracellular matrix as dermal substitute

Biomedical Materials
Dhakshinamoorthy SundaramurthiSwaminathan Sethuraman

Abstract

Electrospinning is a versatile technique to make biomimetic and nanostructured scaffolds for skin tissue engineering. In this study we have electrospun and characterized chitosan (C)-poly(vinyl alcohol) (PVA) blend nanofibers as dermal substitutes and compared with 2D C-PVA films. The in vitro characterization of the C-PVA nanofibers and 2D films were evaluated using mouse 3T3 fibroblast cells and our results demonstrated that the cells adhered and proliferated on the surface of C-PVA nanofibers. In our animal studies, the implantation of C-PVA nanofibers along with topical administration of growth factor R-Spondin 1 on full thickness wounds created on rats showed 98.6% wound closure after two weeks post-surgery. The catalase and superoxide dismutase activity of the healing tissue was significantly higher in the groups treated with topical administration of growth factor and C-PVA nanofibers (p < 0.05). Thus these C-PVA nanofibers along with novel growth factor are promising new biomaterials that could be used as dermal substitutes for accelerated wound healing.

References

Jul 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·J N CloreR F Diegelmann
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Nov 1, 1970·Toxicology and Applied Pharmacology·J W MaddenJ N Ryan
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Jun 1, 1999·Journal of Ethnopharmacology·A ShuklaB N Dhawan
Nov 24, 2001·Advanced Drug Delivery Reviews·H UenoT Fujinaga
Apr 4, 2002·International Journal of Food Microbiology·Hong Kyoon NoSamuel P Meyers
Apr 18, 2003·Biomaterials·Eugene Khor, Lee Yong Lim
Mar 17, 2004·Biomaterials·M ShinJ P Vacanti
Nov 24, 2004·Colloids and Surfaces. B, Biointerfaces·L A Smith, P X Ma
May 12, 2005·Biomaterials·Narayan BhattaraiMiqin Zhang
Aug 30, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sashwati RoyChandan K Sen
Oct 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiangchun WangNaoyuki Taniguchi
Feb 7, 2006·The Journal of Surgical Research·Chunmeng ShiTianmin Cheng
Jan 26, 2007·Journal of the Royal Society, Interface·Anthony D Metcalfe, Mark W J Ferguson
Feb 13, 2007·Biomacromolecules·Jessica D Schiffman, Caroline L Schauer
Aug 11, 2007·Biomaterials·Anthony D Metcalfe, Mark W J Ferguson
Oct 30, 2007·Journal of Pharmaceutical Sciences·Joshua S BoatengGillian M Eccleston
Apr 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·H-J LeeJ-K Koh
Jul 22, 2008·Biomaterials·Sangamesh G KumbarCato T Laurencin
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·B Shivananda NayakAnderson Maxwell
Jan 31, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jingsong ZhaoArie Abo
Mar 3, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Hema Sharma DattaBhushan Patwardhan
Dec 22, 2009·Burns : Journal of the International Society for Burn Injuries·Sophie Böttcher-HaberzethErnst Reichmann
Mar 20, 2010·Biomedical Microdevices·Kuikui HuWei Liu
Aug 28, 2010·Journal of Biomedicine & Biotechnology·T D J Heunis, L M T Dicks
Feb 9, 2011·Biomedical Materials·Anuradha SubramanianSwaminathan Sethuraman

❮ Previous
Next ❯

Citations

Jun 5, 2013·Antimicrobial Agents and Chemotherapy·Tiaan D J HeunisLeon M T Dicks
Nov 20, 2012·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·A K Singh, Y R Shenoy
Jan 16, 2014·Stem Cell Research & Therapy·Stefania Elena NavoneEugenio Agostino Parati
Apr 29, 2014·International Journal of Biological Macromolecules·Rui ZhaoCe Wang
May 3, 2014·Nanomedicine·Hye Sung Kim, Hyuk Sang Yoo
Sep 7, 2012·Biotechnology Advances·Asheesh GuptaMichael R Hamblin
Sep 8, 2012·Expert Opinion on Biological Therapy·Rajesh LakshmananSwaminathan Sethuraman
Oct 22, 2015·Journal of Drug Targeting·Goutam RathAmit Kumar Goyal
Nov 19, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Goutam RathAmit Kumar Goyal
May 6, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Yones Pilehvar-SoltanahmadiNosratollah Zarghami
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Manasa NuneSwaminathan Sethuraman
Jul 19, 2012·Journal of Tissue Engineering and Regenerative Medicine·Krishna Kumar SankaranSwaminathan Sethuraman
Aug 27, 2014·Journal of Biomaterials Science. Polymer Edition·Krishna Kumar SankaranSwaminathan Sethuraman
Feb 8, 2014·Journal of Biomaterials Science. Polymer Edition·Purushothaman KuppanUma Maheswari Krishnan
Oct 7, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Douglas R MarquesJulie E Gough
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Goutam RathAmit Kumar Goyal
Jul 19, 2013·Journal of Biomaterials Science. Polymer Edition·Ranjithkumar RavichandranUma Maheswari Krishnan
Sep 26, 2014·Annals of Biomedical Engineering·Dhakshinamoorthy SundaramurthiSwaminathan Sethuraman
Jun 2, 2017·TheScientificWorldJournal·José Carlos Viana RibeiroVilma Lima
May 15, 2018·Tissue Engineering. Part a·Heejung ImYoungmee Jung
Mar 14, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Antonios KeirouzNorbert Radacsi
Aug 23, 2016·Advanced Healthcare Materials·Mohammad Hossein MohammadiAmir Sanati-Nezhad
Aug 19, 2018·Journal of Materials Science. Materials in Medicine·Merin Sara ThomasLaly A Pothen
Dec 23, 2017·Advanced Healthcare Materials·Mohammadali SheikholeslamSaeid Amini-Nik
Oct 9, 2020·International Forum of Allergy & Rhinology·Tao ZhangHaihong Tang
Mar 26, 2021·Journal of Biomedical Materials Research. Part a·Armin AmirsadeghiSeyeddeh-Sara Hashemi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved