Electrospun PCL/mupirocin and chitosan/lidocaine hydrochloride multifunctional double layer nanofibrous scaffolds for wound dressing applications

International Journal of Nanomedicine
Xiaoming LiBo Zhang

Abstract

An ideal wound dressing should exhibit good biocompatibility, minimize pain and infection, absorb excess exudates, and maintain a moist environment. However, few clinical products meet all these needs. Therefore, the aim of this study was to fabricate a multifunctional double layer nanofibrous scaffolds (DLS) as a potential material for wound dressing. The scaffold was formed from mupirocin and lidocaine hydrochloride homogeneously incorporated into polycaprolactone as the first layer of scaffolds and chitosan as the second layer of scaffolds nanofibers through electrospinning. The fabricated nanofibrous scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and measurement of swelling ratio, contact angle, drug release, and mechanical properties. Furthermore, antibacterial assessment, live/dead cell assays, and MTT assays were used to investigate the antibacterial activity and cytotoxicity of the nanofibrous scaffolds. The morphology of the nanofibrous scaffolds was studied by scanning electron microscopy, showing successful nanofibrous scaffolds. Fourier transform infrared spectroscopy demonstrated the successful inc...Continue Reading

Citations

Jun 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandra Elena StoicaAlexandru Mihai Grumezescu
Jul 8, 2020·Materials·Alexandra Elena StoicaAlexandru Mihai Grumezescu
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Chandravati YadavPradip K Maji
Feb 13, 2021·Pharmaceutics·Mariana F P GraçaAndré F Moreira
Sep 8, 2021·Journal of Biomaterials Science. Polymer Edition·Yifan HuangBinjie Xin
Oct 30, 2021·Applied Biochemistry and Biotechnology·Chenchen XieZuobin Wang

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scanning electron microscopy
differential scanning calorimetry
fluorescence microscopy

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