Abstract
An ideal wound dressing should exhibit good biocompatibility, minimize pain and infection, absorb excess exudates, and maintain a moist environment. However, few clinical products meet all these needs. Therefore, the aim of this study was to fabricate a multifunctional double layer nanofibrous scaffolds (DLS) as a potential material for wound dressing. The scaffold was formed from mupirocin and lidocaine hydrochloride homogeneously incorporated into polycaprolactone as the first layer of scaffolds and chitosan as the second layer of scaffolds nanofibers through electrospinning. The fabricated nanofibrous scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and measurement of swelling ratio, contact angle, drug release, and mechanical properties. Furthermore, antibacterial assessment, live/dead cell assays, and MTT assays were used to investigate the antibacterial activity and cytotoxicity of the nanofibrous scaffolds. The morphology of the nanofibrous scaffolds was studied by scanning electron microscopy, showing successful nanofibrous scaffolds. Fourier transform infrared spectroscopy demonstrated the successful inc...Continue Reading
Citations
Jul 20, 2019·Journal of Biomaterials Science. Polymer Edition·Huilin YeYi Man
Mar 4, 2020·Biomolecules·Peiwen YeFenghuan Wei
May 10, 2020·Materials·Shokoh ParhamFilippo Berto
May 13, 2020·Platelets·Shaochuan WangJun Fei
Jun 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandra Elena StoicaAlexandru Mihai Grumezescu
May 28, 2020·Materials·Alexa-Maria CroitoruClaudiu Florin Turculet
Feb 25, 2020·Biomedical Materials·Hualin ZhangWen Zhang
Apr 10, 2019·Polymers·Saravana Kumar JaganathanAhmad Zahran Md Khudzari
Jul 8, 2020·Materials·Alexandra Elena StoicaAlexandru Mihai Grumezescu
May 28, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mahdi ZafariEsmaeel Sharifi
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Chandravati YadavPradip K Maji
Feb 13, 2021·Pharmaceutics·Mariana F P GraçaAndré F Moreira
May 1, 2021·Pharmaceutics·Marko MilojevićTina Maver
Jun 5, 2021·Journal of Biomedical Nanotechnology·Cuizhen SunQiujin Huang
Jan 19, 2021·ACS Biomaterials Science & Engineering·Shuang YangBo Zhang
Sep 8, 2021·Journal of Biomaterials Science. Polymer Edition·Yifan HuangBinjie Xin
Oct 30, 2021·Applied Biochemistry and Biotechnology·Chenchen XieZuobin Wang