Electrospun PEGylated PLGA nanofibers for drug encapsulation and release

Materials Science & Engineering. C, Materials for Biological Applications
Leqiang ZhangXiangyang Shi

Abstract

We report the fabrication of electrospun nanofibers of polyethylene glycol (PEG)-modified poly (lactic-co-glycolic acid) (PLGA) with a fast release profile for biomedical applications. In this work, PLGA was first covalently modified with methoxy poly (ethylene glycol) amine (mPEG-NH2). The formed PEGylated PLGA (PLGA-PEG) was then mixed with a model drug amoxicillin (AMX) for subsequent fabrication of drug-loaded electrospun nanofibers. The synthesized PLGA-PEG conjugate and the formed drug-loaded PLGA-PEG nanofibers were characterized using different techniques. We show that the modification of PEG does not lead to an appreciable change in the uniform and smooth morphology of PLGA nanofibers. Importantly, the PEGylation modification affords a faster release profile of the encapsulated drug than pure PLGA nanofibers without PEGylation, which may be ascribed to the improved hydrophilicity of the PLGA-PEG polymer. Furthermore, antibacterial activity assay data reveal that the drug-loaded PLGA-PEG nanofibers are able to inhibit the growth of a model bacterium S. aureus. Finally, the hemocompatibility of the drug-loaded PLGA-PEG nanofibers was evaluated by hemolysis and anticoagulant assays, and the cytocompatibility of the fibers...Continue Reading

Citations

Aug 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shan YeWei Shao
Jul 2, 2020·International Journal of Nanomedicine·Saeid MaghsoudiLobat Tayebi
Apr 17, 2019·Nanomaterials·S M Shatil ShahriarYong-Kyu Lee
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Ying MaoLu Wang
Jan 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Atta Ur Rehman KhanXiumei Mo
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesco BoschettoGiuseppe Pezzotti

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