Electrospun poly(ε-caprolactone)-based skin substitutes: In vivo evaluation of wound healing and the mechanism of cell proliferation

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Robin AugustineSabu Thomas

Abstract

In the present study, we have fabricated electrospun poly(ε-caprolactone)-based membranes, characterized and studied the in vivo cell migration and proliferation and wound healing activity. Moreover, we did not seed any cells prior to the animal implantation and we could observe excellent fibroblast attachment and cell proliferation. Further full thickness excision wound on guinea pig completely healed within 35 days. We could reach in an assumption that the enhanced cell proliferation and wound healing might be due to the surface degradation of the polymer under physiological conditions and the formation of functional groups like hydroxyl and carboxyl groups that promoted cell proliferation in a cell adhesion protein mediated mechanism. This study is a novel tissue engineering concept for the reconstruction of a damaged tissue without the in vitro cell seeding and proliferation prior to the in vivo implantation. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1445-1454, 2015.

References

Jul 1, 1979·The Journal of Investigative Dermatology·C H Daly, G F Odland
Jun 1, 1990·Journal of Biomedical Materials Research·T KokuboT Yamamuro
Jul 1, 1994·Biomaterials·J H LeeHaeshin Lee
Dec 16, 1998·Journal of Colloid and Interface Science·J H LeeH B Lee
Nov 7, 1999·Journal of Colloid and Interface Science·C C Dupont-GillainP G Rouxhet
Dec 11, 1999·Journal of Biomaterials Science. Polymer Edition·E A Vogler
Apr 12, 2002·Journal of Biomedical Materials Research·Wan-Ju LiFrank Ko
Jul 31, 2003·Journal of Biomedical Materials Research. Part a·Benjamin G KeselowskyAndrés J García
Apr 30, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Abul Kalam AzadWillem Frans Stevens
Jul 21, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dhirendra S KattiCato T Laurencin
Sep 24, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·A K LynnW Bonfield
Sep 25, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yanzhong ZhangZheng-Ming Huang
Sep 25, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Myung-Seob KhilKeun-Hyung Lee
Jun 1, 2006·Artificial Organs·Jayarama Reddy VenugopalSeeram Ramakrishna
Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jianhua WeiYutaka Oda
Nov 2, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dae-Hyun LewDennis P Orgill
Aug 9, 2007·Colloids and Surfaces. B, Biointerfaces·Zuwei MaChangyou Gao
Mar 4, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sascha MaretschekThomas Kissel
Feb 21, 2009·Journal of Biomaterials Science. Polymer Edition·Jed JohnsonJohn Lannutti
Feb 24, 2009·Tissue Engineering. Part a·Heather M Powell, Steven T Boyce
Jun 10, 2009·Journal of Nanoscience and Nanotechnology·C HenriquesJ A M C Silva
Sep 16, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marco C BottinoGregg M Janowski
Feb 16, 2011·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Ahmad Sukari HalimShah Jumaat Mohd Yussof
Sep 4, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rubén García-PumarinoJuan Manuel Bellón
Oct 25, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Victor LeungFrank Ko
Jan 11, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·April L HarkinsChieu D Tran
Mar 26, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Thomas J KoobGuilhem Denozière
Mar 29, 2014·Journal of Biomedical Materials Research. Part a·Zeynep KarahaliloğluThomas J Webster

Citations

Aug 23, 2020·International Journal of Molecular Sciences·Abdulaziz Ali AlghamdiTaieb Aouak
Jan 7, 2021·Marine Biotechnology·Matheus Almeida CruzAna Claudia Muniz Rennó

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.