Electrospun Polymers in Cartilage Engineering-State of Play

Frontiers in Bioengineering and Biotechnology
Elif Nur Yilmaz, Dimitrios I Zeugolis

Abstract

Articular cartilage defects remain a clinical challenge. Articular cartilage defects progress to osteoarthritis, which negatively (e.g., remarkable pain, decreased mobility, distress) affects millions of people worldwide and is associated with excessive healthcare costs. Surgical procedures and cell-based therapies have failed to deliver a functional therapy. To this end, tissue engineering therapies provide a promise to deliver a functional cartilage substitute. Among the various scaffold fabrication technologies available, electrospinning is continuously gaining pace, as it can produce nano- to micro- fibrous scaffolds that imitate architectural features of native extracellular matrix supramolecular assemblies and can deliver variable cell populations and bioactive molecules. Herein, we comprehensively review advancements and shortfalls of various electrospun scaffolds in cartilage engineering.

References

Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V RosenJ M Wozney
Dec 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Muir
Feb 7, 1997·Cell·S J MorrisonD J Anderson
Nov 19, 1997·Arthritis and Rheumatism·B V ShlopovK A Hasty
Oct 24, 1998·The Journal of Orthopaedic and Sports Physical Therapy·N P CohenV C Mow
Oct 29, 1998·Biochemical and Biophysical Research Communications·C R FlanneryB Caterson
May 13, 1999·Nature Genetics·W BiB de Crombrugghe
Feb 16, 2000·Biomaterials·J S Temenoff, A G Mikos
Oct 18, 2001·Clinical Orthopaedics and Related Research·A R PooleS Laverty
Dec 26, 2001·Tissue Engineering·M A SlivkaG G Niederauer
Nov 15, 2002·Journal of Cell Science·Vicki ChurchPhilippa Francis-West
Feb 5, 2003·The International Journal of Biochemistry & Cell Biology·Charles W Archer, Philippa Francis-West
Aug 22, 2003·Journal of Biomechanical Engineering·Leonidas G AlexopoulosFarshid Guilak
Nov 19, 2003·Journal of Biomedical Materials Research. Part a·Wan-Ju LiRocky S Tuan
Feb 6, 2004·Journal of Cell Science·Gary P DowthwaiteCharles W Archer
May 18, 2004·Arthritis and Rheumatism·Saifeddin AlsalamehMartin Lotz
Jun 29, 2004·Applied Microbiology and Biotechnology·E Lavik, R Langer
Dec 1, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Tian-Fang LiDi Chen
Jan 8, 2005·Clinics in Sports Medicine·Andrew D PearleScott A Rodeo
Sep 1, 2005·Journal of Biomaterials Science. Polymer Edition·Anuradha SubramanianHsin-Yi Lin
Sep 28, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Véronique Lefebvre, Patrick Smits
Dec 3, 2005·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Bodo KurzMichael Schünke
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Denise L CecilRobert Terkeltaub
Jan 28, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tatsuya ShimizuTeruo Okano
May 30, 2006·Journal of Biomechanics·Ivan MartinDavid Wendt
Jun 15, 2006·Tissue Engineering·Quynh P PhamAntonios G Mikos
Aug 8, 2006·Tissue Engineering·Wan-Ju LiRocky S Tuan
Jun 1, 2007·Tissue Engineering·Jin NamJohn Lannutti
Dec 18, 2007·Biomaterials·Lanti YangJan Feijen
Feb 12, 2008·Biomacromolecules·Anna ThorvaldssonPernilla Walkenström
Mar 4, 2008·Biomaterials·Dimitrios I ZeugolisMichael Raghunath

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Citations

Dec 5, 2020·Advanced Healthcare Materials·Shuo WangTreena Livingston Arinzeh
Jan 5, 2021·JOR Spine·Andrea De PieriKarin Wuertz-Kozak
Dec 10, 2020·Materials·Daniella Alejandra Pompa-MonroyLuis Jesús Villarreal-Gómez

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