Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing

International Journal of Biological Macromolecules
Afeesh Rajan UnnithanCheol Sang Kim

Abstract

Post-menopausal wound care management is a substantial burden on health services, since there are an increased number of elderly populations linked with age-related delayed wound healing. The controlled estrogen replacement can accelerate healing of acute cutaneous wounds, linked to its potent anti-inflammatory activity. The electrospinning technique can be used to introduce the desired therapeutic agents to the nanofiber matrix. So here we introduce a new material for wound tissue dressing, in which a polyurethane-dextran composite nanofibrous wound dressing material loaded with β-estradiol was obtained through electrospinning. Dextran can promote neovascularization and skin regeneration in chronic wounds. This study involves the characterization of these nanofibers and analysis of cell growth and proliferation to determine the efficiency of tissue regeneration on these biocomposite polymer nanofibrous scaffolds and to study the possibility of using it as a potential wound dressing material in the in vivo models.

References

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Citations

May 18, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Farideh Mohammadian, Ali Eatemadi
Jun 30, 2016·Journal of Biomedical Materials Research. Part a·Kuwabo MubyanaDavid T Corr
Apr 6, 2020·Biotechnology and Applied Biochemistry·Hessam RezaeiMohammadali Sahebalzamani
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chenyu WangJianxun Ding
Jan 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arathyram Ramachandra Kurup SasikalaCheol Sang Kim
Sep 3, 2020·Membranes·Mariela TorielloLeonard D Tijing
Jul 6, 2021·Macromolecular Bioscience·Pingli WuGuoming Sun

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