Electrospun poly(vinyl) alcohol/collagen nanofibrous scaffold hybridized by graphene oxide for accelerated wound healing

The International Journal of Artificial Organs
Rethinam SenthilNallathambi Gobi

Abstract

In this study, a blend of synthetic polymer (poly(vinyl) alcohol), natural polymer (collagen type I from fish bone), and graphene oxide nanoparticles is used to fabricate a composite nanofibrous scaffold, by electrospinning, for their potential application in accelerated wound healing. The scaffold was characterized for its physicochemical and mechanical properties. In vitro studies were carried out using human keratinocyte cell line (HaCaT) which proved the biocompatibility of the scaffold. In vivo study using mice model was carried out and the healing pattern was evaluated using histopathological studies. Scaffold prepared from poly(vinyl) alcohol, collagen type I from fish bone, and graphene oxide possessed better physicochemical and mechanical properties. In addition, in vivo and in vitro studies showed its accelerated wound healing properties. The scaffold with required strength and biocompatibility may be tried as a wound dressing material in large animals after getting necessary approval.

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Citations

Nov 23, 2018·Current Drug Targets·Emma Polonio-AlcaláTeresa Puig
Dec 20, 2019·Journal of Biomaterials Science. Polymer Edition·Chengwei YangKuihua Zhang
Jun 11, 2020·Molecular Pharmaceutics·Shahriar SharifiMorteza Mahmoudi
Mar 18, 2021·ACS Biomaterials Science & Engineering·Jamie J GrantAilish Breen

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Methods Mentioned

BETA
transmission electron microscopy

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