Electrospinning is a versatile technique that enables the development of nanofiber-based biomaterial scaffolds. Scaffolds can be generated that are useful for tissue engineering and regenerative medicine since they mimic the nanoscale properties of certain fibrous components of the native extracellular matrix in tissues. Silk is a natural protein with excellent biocompatibility, remarkable mechanical properties as well as tailorable degradability. Integrating these protein polymer advantages with electrospinning results in scaffolds with combined biochemical, topographical and mechanical cues with versatility for a range of biomaterial, cell and tissue studies and applications. This review covers research related to electrospinning of silk, including process parameters, post treatment of the spun fibers, functionalization of nanofibers, and the potential applications for these material systems in regenerative medicine. Research challenges and future trends are also discussed.
Six-year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions
Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium
Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro
Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques
Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters
A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells
Effect of organosoluble salts on the nanofibrous structure of electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Formation of silk fibroin matrices with different texture and its cellular response to normal human keratinocytes
Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing
Grafting of gelatin on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell Orientation
Characterization of the surface biocompatibility of the electrospun PCL-collagen nanofibers using fibroblasts
Time-resolved structural investigation of regenerated silk fibroin nanofibers treated with solvent vapor
Biomimetic nanofibrous scaffolds: preparation and characterization of chitin/silk fibroin blend nanofibers
Modulation of anisotropy in electrospun tissue-engineering scaffolds: Analysis of fiber alignment by the fast Fourier transform
The effect of gradually graded shear stress on the morphological integrity of a huvec-seeded compliant small-diameter vascular graft
Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-epsilon-caprolactone and a collagen/poly-epsilon-caprolactone blend
Morphology and structure of electrospun mats from regenerated silk fibroin aqueous solutions with adjusting pH
Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds
Response of human mesenchymal stem cells to patterned and randomly oriented poly(vinyl alcohol) nano-fibrous scaffolds surface-modified with Arg-Gly-Asp (RGD) ligand
Significantly reinforced composite fibers electrospun from silk fibroin/carbon nanotube aqueous solutions
Reduction of inflammatory responses and enhancement of extracellular matrix formation by vanillin-incorporated poly(lactic-co-glycolic acid) scaffolds
Preparation and characterization of biomimetic silk fibroin/chitosan composite nanofibers by electrospinning for osteoblasts culture
Activation of the ubiquitin proteasome pathway by silk fibroin modified chitosan nanoparticles in hepatic cancer cells
Mammary epithelial cell adhesion, viability, and infiltration on blended or coated silk fibroin-collagen type I electrospun scaffolds
Construction of engineering adipose-like tissue in vivo utilizing human insulin gene-modified umbilical cord mesenchymal stromal cells with silk fibroin 3D scaffolds
Fabrication of conductive electrospun silk fibroin scaffolds by coating with polypyrrole for biomedical applications
Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels
Fabrication of electrospun silk fibroin scaffolds coated with graphene oxide and reduced graphene for applications in biomedicine
Developing scaffolds for tissue engineering using the Ca2+-induced cold gelation by an experimental design approach
Creation of macropores in electrospun silk fibroin scaffolds using sacrificial PEO-microparticles to enhance cellular infiltration
Silk fibroin scaffold as a potential choice for female pelvic reconstruction: A study on the biocompatibility in abdominal wall, pelvic, and vagina
Fabrication and characterization of nano-fibrous bilayer composite for skin regeneration application
Adult Stem Cells
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.
Cajal Bodies & Gems
Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.
Allogenic & Autologous Therapies
Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.
Advances in biomaterial engineering have permitted the development of sophisticated drug-releasing materials with a biomimetic 3D support that allow a better control of the microenvironment of transplanted cells. Here is the latest research.
Adhesion Molecules in Health and Disease
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.