Electrospun triaxial nanofibers with middle blank cellulose acetate layers for accurate dual-stage drug release.

Carbohydrate Polymers
Yaoyao YangDeng-Guang Yu

Abstract

The combination of complex nanostructures with carbohydrate polymers can provide a strong platform for promoting the development of novel drug delivery systems. In this study, tri-layer core-shell nanofibers F2 with discrete drug distributions were prepared using cellulose acetate (CA) as a key filament-forming polymeric matrix and ketoprofen (KET) as a model drug. The discrete distribution was characterized by inserting a bank CA layer between the CA/KET core layer and the PVP/KET outer layer through a modified triaxial electrospinning. Compared with the traditional core-shell nanofibers F1, the tri-layer nanofibers F2 with drug discrete distributions provided better drug dual-stage release profiles in terms of accurate release contents at the first stage and longer time period sustained release at the second stage. Despite having the same components (drug, soluble PVP, and insoluble CA) and similar linear morphologies, core-shell nanofibers F1 and tri-layer nanofibers F2 exhibited significantly different functional performances in providing dual-stage release. The different structure-performance relationships of the two types of nanofibers have played their important roles on manipulating the accuracy of dual-stage drug contr...Continue Reading

Citations

Feb 2, 2021·Biomaterials Science·M Gregory Grewal, Christopher B Highley
Feb 25, 2021·Research : a Science Partner Journal·Rani MataChangyou Gao
Aug 28, 2020·International Journal of Biological Macromolecules·Hussien Ahmed AbbasHanan H Beherei
May 10, 2021·International Journal of Biological Macromolecules·Deepak KumarPatit P Kundu
Jul 6, 2021·Science and Technology of Advanced Materials·Nanami FujisawaMitsuhiro Ebara
Nov 6, 2020·Journal of the Mechanical Behavior of Biomedical Materials·R KyselicaR Anton
Dec 17, 2021·ACS Biomaterials Science & Engineering·Chenxi LiYong Liu

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