May 1, 2020

Electrostatic Characteristics of SARS-CoV-2 Spike and Human ACE2 Protein Variations Predict Mutable Binding Efficacy

BioRxiv : the Preprint Server for Biology
Scott P Morton, J. L. Phillips

Abstract

SARS-CoV-2 is a novel pneumonia virus that emerged from bats to crossover into humans in late 2019. As the global pandemic ensues, scientist are working to evaluate the virus and develop a vaccine to counteract the deadly disease that has impacted lives across the entire globe. We present an electrostatic analysis at the structural level that predicts different variations of SARS-CoV-2 in complex with human angiotensin-converting enzyme 2 (ACE2) variants impact forces involved with interactions between the proteins. Two of six SARS-CoV-2 variations having greater electric forces at pH levels consistent with nasal secretions and significant variations in force across all five variants of ACE2. While five out of six SARS-CoV-2 variations have relatively consistent forces at pH levels associated with normal lung function, and one SARS-CoV-2 variant that has low potential across a wide range of pH. These predictions indicate that variants of SARS-CoV-2 and human ACE2 in certain combinations could potentially play a role in increased binding efficacy of SARS-CoV-2 in vivo.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Size
Genome
Genes
Ethnic Group
Genomics
Cell Growth
South
Shox Gene With Short Stature
Statistical Technique
Analysis

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.