Electrostatic charge activates inflammatory vanilloid (VR1) receptors

Neurotoxicology
B VeronesiM Oortgiesen

Abstract

The pathophysiology of neurogenic inflammation culminates in the overt symptoms of tissue inflammation through a series of events which are initiated by the activation of vanilloid receptors (VR1). This study was designed to test the hypothesis that a sufficiently negative, electrostatic charge carried on a particulate matter (PM) particle, could acquire a cloud of protons sufficient to activate proton-sensitive VR1 receptors and acid-sensitive ionic channels (ASICs) pathways. For this, nanometer-sized, synthetic polystyrene micells (SPM) or those charged with chemical groups (e.g. diamino, carboxyl) were used. These chemical groups imparted either a net positive (i.e. diamino) or negative (i.e. carboxyl) charge on the SPM when suspended in a neutral ionic medium. The zeta potential, a measure of the SPM's electronegativity, was taken in both cell culture nutrient medium and in ultraviolet light-distilled water (UV-DW). In both vehicles, the rank order of electronegativity (most to least negative) was carboxyl > polystyrene > diamino-SPM. Individual types of SPM were exposed to human, immortalized bronchial-tracheal epithelial cells (i.e. BEAS-2B) and endpoints of biological activation (i.e. membrane depolarization, increases i...Continue Reading

References

Jan 1, 1991·International Archives of Allergy and Applied Immunology·P J Barnes
Oct 1, 1991·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·H W SchultisE Riedel
Dec 1, 1994·Trends in Neurosciences·S Bevan, P Geppetti
Jan 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·W M Elliott, N Auersperg
Apr 1, 1993·American Journal of Respiratory Cell and Molecular Biology·P BalukD M McDonald
Jan 28, 1993·Nature·M J Berridge
May 29, 1998·Brain Research. Molecular Brain Research·T BíróP M Blumberg
Dec 29, 1998·The Journal of Allergy and Clinical Immunology·A J Polito, D Proud
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·P R MillsJ L Devalia
Feb 9, 2000·Trends in Pharmacological Sciences·P M ZygmuntE D Högestätt
Apr 27, 2000·Allergy·G F JoosR A Pauwels
Sep 28, 2000·Trends in Neurosciences·A Szallasi, V Di Marzo
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·J M WelchP H Reinhart
Feb 13, 2001·Trends in Pharmacological Sciences·D Piomelli
Jul 18, 2001·The Journal of Biological Chemistry·A BaronM Lazdunski
Feb 7, 2002·Neurotoxicology·B Verones, M Oortgiesen
Apr 5, 2002·Trends in Pharmacological Sciences·Martin J GunthorpeJohn B Davis
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jennelle Durnett Richardson, Michael R Vasko
May 2, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher A ReillyGarold S Yost

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Citations

Jan 11, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Elisa GhelfiBeatriz Gonzalez-Flecha
Dec 14, 2011·Molecular Pharmacology·Cassandra E Deering-RiceChristopher A Reilly
Mar 2, 2006·Environmental Health Perspectives·John M VeranthGarold S Yost
Jul 30, 2015·The International Journal of Biochemistry & Cell Biology·Alessandra GilardinoDavide Lovisolo
Sep 29, 2011·Toxicology and Applied Pharmacology·Ryohei Miyata, Stephan F van Eeden
Sep 1, 2009·Trends in Neurosciences·Michelle L Block, Lilian Calderón-Garcidueñas
Oct 23, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·John E RepineDwight M Smith
Jun 4, 2015·American Journal of Respiratory Cell and Molecular Biology·Cassandra E Deering-RiceChristopher A Reilly
Jan 1, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chia T Thach, Jacob N Finkelstein
Aug 14, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Todd L WattersonRoger A Coulombe
Aug 6, 2005·Progress in Neurobiology·Michelle L Block, Jau-Shyong Hong
Nov 25, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·N AgopyanS A Simon
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M L BlockB Veronesi
Nov 8, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jong-Khing HuangChung-Ren Jan

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