Electrostatic coating enhances bioavailability of insecticides and breaks pyrethroid resistance in mosquitoes

Proceedings of the National Academy of Sciences of the United States of America
Rob AndriessenMarit Farenhorst

Abstract

Insecticide resistance poses a significant and increasing threat to the control of malaria and other mosquito-borne diseases. We present a novel method of insecticide application based on netting treated with an electrostatic coating that binds insecticidal particles through polarity. Electrostatic netting can hold small amounts of insecticides effectively and results in enhanced bioavailability upon contact by the insect. Six pyrethroid-resistant Anopheles mosquito strains from across Africa were exposed to similar concentrations of deltamethrin on electrostatic netting or a standard long-lasting deltamethrin-coated bednet (PermaNet 2.0). Standard WHO exposure bioassays showed that electrostatic netting induced significantly higher mortality rates than the PermaNet, thereby effectively breaking mosquito resistance. Electrostatic netting also induced high mortality in resistant mosquito strains when a 15-fold lower dose of deltamethrin was applied and when the exposure time was reduced to only 5 s. Because different types of particles adhere to electrostatic netting, it is also possible to apply nonpyrethroid insecticides. Three insecticide classes were effective against strains of Aedes and Culex mosquitoes, demonstrating that...Continue Reading

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Citations

Apr 26, 2016·Malaria Journal·Jeroen SpitzenWillem Takken
Jun 17, 2016·Malaria Journal·Lucy S TustingJo Lines
Jun 18, 2016·Journal of Medical Entomology·Bingqian LiuChangliang Zhu
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Apr 12, 2017·Journal of Medical Entomology·Juxin GuoChangliang Zhu
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Apr 11, 2021·Tropical Medicine & International Health : TM & IH·Pedram EbrahimnejadAhmadali Enayati

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