Electrostatic complementarity at protein/protein interfaces

Journal of Molecular Biology
A J McCoyP M Colman

Abstract

Calculation of the electrostatic potential of protein-protein complexes has led to the general assertion that protein-protein interfaces display "charge complementarity" and "electrostatic complementarity". In this study, quantitative measures for these two terms are developed and used to investigate protein-protein interfaces in a rigorous manner. Charge complementarity (CC) was defined using the correlation of charges on nearest neighbour atoms at the interface. All 12 protein-protein interfaces studied had insignificantly small CC values. Therefore, the term charge complementarity is not appropriate for the description of protein-protein interfaces when used in the sense measured by CC. Electrostatic complementarity (EC) was defined using the correlation of surface electrostatic potential at protein-protein interfaces. All twelve protein-protein interfaces studied had significant EC values, and thus the assertion that protein-protein association involves surfaces with complementary electrostatic potential was substantially confirmed. The term electrostatic complementarity can therefore be used to describe protein-protein interfaces when used in the sense measured by EC. Taken together, the results for CC and EC demonstrate t...Continue Reading

References

Jun 1, 1992·Protein Science : a Publication of the Protein Society·A KarshikovS R Stone
Sep 5, 1992·Journal of Molecular Biology·W R TulipP M Colman
Jan 1, 1992·Progress in Biophysics and Molecular Biology·J Novotny, K Sharp
Sep 20, 1991·Journal of Molecular Biology·T J RydelR Huber
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S SheriffD R Davies
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E A PadlanD R Davies
Jan 1, 1968·Advances in Protein Chemistry·G N Ramachandran, V Sasisekharan
Jan 1, 1984·Progress in Biophysics and Molecular Biology·E N Baker, R E Hubbard
Mar 15, 1984·Journal of Molecular Biology·A A Rashin, B Honig
Aug 25, 1983·Journal of Molecular Biology·D J Barlow, J M Thornton
Jun 1, 1994·Protein Science : a Publication of the Protein Society·E DemchukR C Wade
Jan 20, 1995·Science·T Clackson, J A Wells
Jul 7, 1995·Journal of Molecular Biology·R M Jackson, M J Sternberg
Jul 28, 1995·The Journal of Biological Chemistry·J LescarP M Alzari
Oct 1, 1994·Journal of Biomolecular Structure & Dynamics·S P SlagleS Subramaniam
Jan 1, 1995·Proteins·J Janin
Jan 1, 1995·Progress in Biophysics and Molecular Biology·S Jones, J M Thornton
May 26, 1995·Science·B Honig, A Nicholls
Jan 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B C Braden, R J Poljak
Feb 1, 1994·Protein Science : a Publication of the Protein Society·Z S Hendsch, B Tidor
Dec 20, 1993·Journal of Molecular Biology·M C Lawrence, P M Colman
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·T N BhatR J Poljak
Feb 23, 1996·Science·P A PattenP G Schultz

❮ Previous
Next ❯

Citations

Sep 11, 2007·Journal of Molecular Modeling·Surendra S Negi, Werner Braun
Sep 14, 2007·The Protein Journal·Changhui YanVasant Honavar
Jul 31, 2013·Quarterly Reviews of Biophysics·Alexey V Onufriev, Emil Alexov
Apr 22, 2011·ACS Chemical Biology·Sameer S KulkarniRoman Manetsch
Aug 19, 2000·The Biochemical Journal·S RomagnoliH Molinari
Mar 26, 2008·The Journal of Biological Chemistry·Thiagarajan SrimathiYoung Chul Park
Apr 7, 2009·Briefings in Bioinformatics·Iakes EzkurdiaMichael L Tress
Jun 26, 2003·Nucleic Acids Research·Razif R GabdoullineDirk Walther
Mar 11, 2009·Nucleic Acids Research·Kyu-il ChoDoheon Lee
Jun 17, 2011·Protein Engineering, Design & Selection : PEDS·Saliha Ece Acuner OzbabacanOzlem Keskin
Jun 5, 2012·Protein Engineering, Design & Selection : PEDS·Daisuke KurodaHaruki Nakamura
Dec 14, 2006·Acta Crystallographica. Section D, Biological Crystallography·Jan GruberMartin E M Noble
Mar 23, 2006·Annual Review of Immunology·Markus G RudolphIan A Wilson
Aug 27, 2005·BMC Bioinformatics·Sungsam GongJong Bhak
Oct 3, 2006·PLoS Computational Biology·Wan Kyu KimMichael Schroeder
Aug 31, 2013·PLoS Computational Biology·Eric T C WongJörg Gsponer
Aug 2, 2013·Journal of Biochemistry·Hidetoshi InoueYoshitake Maeda
Dec 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·J N VargheseR J Simpson
Oct 6, 2015·Biomolecules·Junji IwaharaLevani Zandarashvili
Jun 17, 2016·Bioinformatics·Sankar Basu, Björn Wallner
Sep 24, 2016·The Journal of Physical Chemistry Letters·Song-Ho Chong, Sihyun Ham
Nov 4, 2016·Nature·Jacques-Philippe ColletierDavid S Eisenberg
Apr 23, 2016·Scientific Reports·Wenjing RuanTao Wu
Nov 21, 2013·Scientific Reports·Ye LiDapeng Cao
Jul 5, 2005·Bioorganic & Medicinal Chemistry·Mayssam H Ali, Barbara Imperiali
Jan 7, 2009·Biochemical and Biophysical Research Communications·Akiko TonookaNoriyuki Sato
May 21, 2005·Proteins·Andrew J Bordner, Ruben Abagyan
Jun 21, 2005·Journal of Molecular Biology·Dmitry TworowskiMark G Safro
Jun 28, 2017·Physical Chemistry Chemical Physics : PCCP·Anne StrateRalf Ludwig
Jun 20, 2017·Journal of Molecular Modeling·Sankar Basu, Debasish Mukharjee
Apr 12, 2001·Protein Engineering·J G MandellL F Ten Eyck
Apr 5, 2001·Protein Engineering·U Samanta, P Chakrabarti
Dec 12, 2001·Protein Engineering·S A RichterR Rudolph
Mar 11, 2004·Journal of Computational Chemistry·Matthias KeilJürgen Brickmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.