Electrostatic droplets assisted synthesis of alginate microcapsules

Drug Delivery and Translational Research
Keng-Shiang HuangYi-Ling Wang

Abstract

This paper demonstrates a proof-of-concept approach for encapsulating the insulin and Fe3O4 nanoparticles into size-controllable alginate microcapsules utilizing the electrostatic droplets (ESD) technique. We have established that the combination of ESD and external gelation is quite effective in producing uniform-sized polymer particles. In addition, using the external gelation technique, the droplets containing a sodium-alginate were gelled in situ by immersion in Ca(2+), Ba(2+), or Cu(2+) ions for a few minutes. The results show that different-type divalent cations caused various surface features to appear on the microcapsules (e.g., cracking, orange peel, pitting, splitting, wrinkling, etc.). The particle size can be adjusted from a few micrometers to ca. 1,000 μm by electrostatic force. The microcapsules can be made magnetic by incorporating a super-paramagnetic nanomaterial (e.g., Fe3O4 nanoparticles) during the preparation. The composite magnetic microcapsules are potential candidates for a magnetic-responsive drug delivery system. In addition, our results show that the encapsulation and in vitro release of a model drug, insulin, can enhance the effect of the controlled release. These microcapsules are addressable by an ...Continue Reading

References

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Citations

Jul 23, 2014·Nanoscale Research Letters·Chih-Hui YangYung-Sheng Lin
Jun 20, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chih-Hui YangKeng-Shiang Huang
Jun 6, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yung-Sheng LinKeng-Shiang Huang
Aug 15, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Keng-Shiang HuangChih-Hui Yang
May 18, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Keng-Shiang HuangWei-Ting Wang
Jun 12, 2014·Electrophoresis·Chih-Hui YangKeng-Shiang Huang
Aug 25, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Dewi Melani Hariyadi, Nazrul Islam
Apr 30, 2015·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Patrick DegenHeinz Rehage
Nov 20, 2012·Electrophoresis·Yung-Sheng LinChen-Ling Hsieh
Apr 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chih-Yu WangChih-Hsin Chen
Aug 14, 2017·ACS Biomaterials Science & Engineering·Niusha NikraveshLiam M Grover

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