PMID: 9440873Jan 24, 1998Paper

Electrostatic endothelial cell transplantation within small-diameter (<6 mm) vascular prostheses: a prototype apparatus and procedure

Cell Transplantation
G L Bowlin, S E Rittgers

Abstract

This article presents a novel, clinically relevant electrostatic endothelial cell transplantation (seeding/sodding) device (U.S. & Foreign Patent Protections Pending) for small-diameter (<6 mm) vascular prostheses. The prototype apparatus was designed and built to tissue engineer 4.0 mm, I.D. GORE-TEX (W.L. Gore & Associates, Inc.) standard wall graft segments varying in length from 4 to 12 cm. The prototype electrostatic endothelial cell transplantation apparatus is composed of an external and internal conductor, aluminum base, end supports, pillow blocks, filling apparatus, electric motor drive system, and a voltage source. The cylindrical capacitor arrangement of the device along with an electrical potential applied across the internal and external conductors creates the unique feature of this endothelial cell transplantation technique, an electric field within the cylindrical capacitor (within the graft lumen) which in turn induces a temporary positive surface charge on the graft (dielectric material) luminal surface. Multiple studies have shown that a positively charged substrate is more conducive to endothelial cell adhesion and morphological maturation (flattening) (1,2, 7,8,10,13-15). This induced positive surface charg...Continue Reading

Citations

Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Prabir Roy-ChaudhuryAlfred K Cheung
Jan 4, 2005·Blood Purification·Prabir Roy-ChaudhurySue C Heffelfinger
Aug 9, 2005·Cardiology Clinics·Prabir Roy-ChaudhurySue C Heffelfinger

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