Electrostatic swelling of bicontinuous cubic lipid phases

Soft Matter
Arwen I I TylerNicholas J Brooks

Abstract

Lipid bicontinuous cubic phases have attracted enormous interest as bio-compatible scaffolds for use in a wide range of applications including membrane protein crystallisation, drug delivery and biosensing. One of the major bottlenecks that has hindered exploitation of these structures is an inability to create targeted highly swollen bicontinuous cubic structures with large and tunable pore sizes. In contrast, cubic structures found in vivo have periodicities approaching the micron scale. We have been able to engineer and control highly swollen bicontinuous cubic phases of spacegroup Im3m containing only lipids by (a) increasing the bilayer stiffness by adding cholesterol and (b) inducing electrostatic repulsion across the water channels by addition of anionic lipids to monoolein. By controlling the composition of the ternary mixtures we have been able to achieve lattice parameters up to 470 Å, which is 5 times that observed in pure monoolein and nearly twice the size of any lipidic cubic phase reported previously. These lattice parameters significantly exceed the predicted maximum swelling for bicontinuous cubic lipid structures, which suggest that thermal fluctuations should destroy such phases for lattice parameters larger ...Continue Reading

References

Apr 13, 1979·Science·J S Patton, M C Carey
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D M AndersonS Leibler
Jan 1, 1993·Biophysical Journal·P O Eriksson, G Lindblom
Jun 5, 1997·Nature·K Simons, E Ikonen
Nov 25, 1998·Biophysical Journal·A S AnderssonG Lindblom
Dec 24, 2002·Biophysical Journal·Vadim CherezovMartin Caffrey
Jun 12, 2003·Journal of the American Chemical Society·Borislav AngelovAndrew Campitelli
Mar 3, 2004·Biophysical Journal·Horia I PetracheJohn F Nagle
Jun 11, 2004·Annual Review of Biochemistry·Jessica E Smotrys, Maurine E Linder
Apr 12, 2006·Physical Review Letters·Charlotte E ConnRichard H Templer
Jun 21, 2006·The Journal of Cell Biology·Zakaria A AlmsherqiYuru Deng
Feb 9, 2007·Nature Reviews. Molecular Cell Biology·Gia K Voeltz, William A Prinz
Jul 28, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Anniina SalonenOtto Glatter
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Apr 25, 2009·Nature Protocols·Martin Caffrey, Vadim Cherezov
Oct 30, 2010·Journal of the American Chemical Society·Cecília LealCyrus R Safinya
Jan 29, 2011·Journal of Structural Biology·G E Schröder-TurkS T Hyde
May 24, 2011·Biochemical Society Transactions·Martin Caffrey
Oct 13, 2011·The Journal of Physical Chemistry. B·Pablo SzekelyUri Raviv
Nov 3, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Renata Negrini, Raffaele Mezzenga
Jun 15, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Deborah L GaterVadim Cherezov
Mar 8, 2014·Science·Robert F Service

❮ Previous
Next ❯

Citations

Feb 13, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Shalene SankhagowitNoah Malmstadt
Jan 15, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Aug 15, 2015·FEBS Letters·Samuel FurseJ Antoinette Killian
Sep 22, 2015·ACS Nano·Hojun Kim, Cecilia Leal
May 18, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Malinda SalimRauzah Hashim
Jun 15, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·L SagalowiczM Michel
Aug 3, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Maria ValldeperasJustas Barauskas
Oct 22, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Leonie van 't HagCharlotte E Conn
Sep 14, 2016·Journal of Colloid and Interface Science·Wye-Khay FongBen J Boyd
Feb 14, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Jiali ZhaiCalum J Drummond
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hojun KimCecilia Leal
Jun 22, 2018·Angewandte Chemie·Hanna M G BarrigaMolly M Stevens
Nov 15, 2018·Physical Chemistry Chemical Physics : PCCP·Beibei HuangShuxing Zhang
Jun 22, 2019·Advanced Materials·Raffaele MezzengaLaurent Sagalowicz
Aug 16, 2017·Scientific Reports·Christopher BrasnettAnnela Seddon
Apr 24, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Livia Salvati ManniRaffaele Mezzenga
Mar 10, 2019·The Journal of Chemical Physics·Reza GhanbariRaffaele Mezzenga
Feb 10, 2018·The Journal of Chemical Physics·Salvatore Assenza, Raffaele Mezzenga
Mar 29, 2020·Science China Materials·Congcong CuiLu Han
Aug 16, 2016·Physical Review Letters·Fabien PaillussonHalim Kusumaatmaja
Dec 29, 2020·Journal of Colloid and Interface Science·Thomas G MeikleCharlotte E Conn
May 17, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Milada VítováSamuel Furse
Jul 2, 2021·Frontiers in Cell and Developmental Biology·Viveka AlfredssonTommy Nylander
Jul 20, 2021·Chemistry and Physics of Lipids·Nina Královič-KanjakováDaniela Uhríková
Oct 3, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Nov 9, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Hanna M G BarrigaNicholas J Brooks
Apr 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Chiara SpezialeRaffaele Mezzenga
Feb 18, 2020·ACS Applied Bio Materials·Valeria CastellettoJanne Ruokolainen
Dec 29, 2020·The Journal of Physical Chemistry Letters·Jiali ZhaiCalum J Drummond
Sep 17, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Nguyen D TienAmin Sadeghpour
Jan 19, 2021·ACS Biomaterials Science & Engineering·Sampa SarkarCalum J Drummond
Jan 11, 2020·Accounts of Chemical Research·Sungmin HaKyoung Taek Kim
Oct 1, 2021·Journal of the American Chemical Society·Zexi XuArwen I I Tyler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.