Electrostatically driven lipid-protein interaction: Answers from FRET

Biochimica Et Biophysica Acta
Fábio FernandesLuís M S Loura

Abstract

Electrostatics govern the association of a large number of proteins with cellular membranes. In some cases, these proteins present specialized lipid-binding modules or membrane targeting domains while in other cases association is achieved through nonspecific interaction of unstructured clusters of basic residues with negatively charged lipids. Given its spatial resolution in the nanometer range, Förster resonance energy transfer (FRET) is a powerful tool to give insight into protein-lipid interactions and provide molecular level information which is difficult to retrieve with other spectroscopic techniques. In this review we present and discuss the basic formalisms of both hetero- and homo-FRET pertinent to the most commonly encountered problems in lipid-protein interaction studies and highlight some examples of implementations of different FRET methodologies to characterize lipid/protein systems in which electrostatic interactions play a crucial role. This article is part of a Special Issue entitled: Lipid-protein interactions.

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Citations

Jan 28, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Michael Richard SandersRebecca Joanne Green
Jul 10, 2019·The Journal of Physical Chemistry. B·Xingyao FengAyumi Hirano-Iwata

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