Electrotonic modulation of the T wave and cardiac memory
Alterations in the sequence of ventricular activation (left bundle branch block occurring spontaneously or induced by atrial pacing; right ventricular pacing) were studied and shown to induce two opposite changes in the order of ventricular repolarization. One, which causes classic secondary T wave changes, occurs and disappears instantaneously, and is proportional in magnitude to the QRS complex but of opposite direction. The other, which requires a long time to reach its maximal effect and to be dissipated, shows the same direction as the abnormal QRS forces but becomes apparent only when normal activation is restored. The former is a well known consequence of prolongation of the activation time, but the latter appears to be modulated by electrotonic interactions occurring during cardiac activation, in such a way that repolarization is delayed in sites where depolarization begins, and accelerated in sites where depolarization terminates. Our study suggests that electrotonically modulated T wave changes show accumulation and memory, and may persist for days or weeks after the provoking stimulus (the change in the activation sequence) is discontinued. The fact that any shift of the activation sequence may produce "pseudoprimary...Continue Reading
Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path
The theoretical and experimental bases of the frontal plane ventricular gradient and its spatial counterpart
Evaluation of QRST isointegral maps in detecting posterior myocardial infarction with and without conduction disturbance
Detection of coronary stenoses by stress echocardiography using a previously implanted pacemaker for ventricular pacing: preliminary report of a new method
Computer simulation of electronic interactions during excitation and repolarisation of myocardial tissue
Reversal of primary and pseudo-primary T wave abnormalities by ventricular pacing. A novel manifestation of cardiac memory
Precordial T-wave inversion of "cardiac memory" pattern after high-dose methylprednisolone pulse therapy
Modeling cardiac electromechanics and mechanoelectrical coupling in dyssynchronous and failing hearts: insight from adaptive computer models
Mathematical model of electrotonic interactions during excitation and repolarisation of myocardial tissue
Repolarization abnormalities after catheter ablation of accessory atrioventricular connections with radiofrequency current
QRST time integral values in 12-lead electrocardiograms before and after radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome
Early rate control in complete atrioventricular block is warranted to prevent electrical remodeling: No role for ventricular activation?
Persistent T-wave changes after radiofrequency catheter ablation of an accessory connection (Wolff-parkinson-white syndrome) are caused by "cardiac memory"
Body surface distribution of significant changes in QRST time-integral values after radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome
Memory T waves after radiofrequency catheter ablation of accessory atrioventricular connections in Wolff-Parkinson-White syndrome
Relationship between QRS duration and repolarization abnormalities in patients with Wolff-Parkinson-White syndrome
Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy
The repolarization-excitability relationship in the human right atrium is unaffected by cycle length, recording site and prior arrhythmias
Upstream stimulation versus downstream stimulation: arrhythmogenesis based on repolarization dispersion in the human heart
Bradycardia dependent QT prolongation and ventricular fibrillation following catheter ablation of the atrioventricular junction with radiofrequency energy
Recent advances in the electrocardiographic diagnosis of myocardial infarction: left bundle branch block and pacing
Inverse relation of body-surface activation-recovery interval and recovery time to activation time in normal subjects: stronger correlation and more heterogeneous distribution in activation-recovery interval than in recovery time
QT-interval turbulence induced by atrial and ventricular extrastimuli in patients with ventricular tachycardia
Electrocardiographic characteristics and main causes of pseudoprimary T wave changes. Significance of concordant and discordant T waves in the human and other animal species
Increased cardiac electrical instability concomitant with pacing induced repolarisation abnormalities
Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents
Cardiovascular Diseases: Risk Factors
Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.
Cardiac Conduction System
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.