PMID: 9437653Jan 23, 1998Paper

Elemental diet-induced bacterial translocation associated with systemic and intestinal immune suppression

JPEN. Journal of Parenteral and Enteral Nutrition
D XuEdwin A Deitch

Abstract

Elemental diets can lead to a loss of intestinal barrier function, promote bacterial translocation, and impair host immune defenses. The purpose of this study was to determine the effects of i.v. and orally administered total parenteral nutrition (TPN) solution on systemic and intestinal immunity and to establish whether supplemental cellulose fiber could improve the impaired immune response. The incidence of bacterial translocation and immune function was quantitated by measuring organ weights, immune cell population levels, and the mitogenic response of lymphocytes from the spleen, mesenteric lymph nodes and Peyer's patches of rats receiving parenteral or enteral TPN solution, with and without fiber supplementation. Parenteral and enterally administered TPN solution promoted bacterial translocation to the mesenteric lymph nodes, reduced immune cell population levels, and decreased the lymphocyte mitogenic response to T- and B-cell mitogens. Supplemental cellulose fiber reduced the incidence of diet-induced bacterial translocation from 84% to 31% (p < .01) and improved immune cell function. To more closely examine the relationship between bacterial translocation and impaired lymphocyte mitogenic activity, rats receiving TPN or...Continue Reading

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Citations

Apr 19, 2003·Journal of Gastroenterology and Hepatology·Ashkan FarhadiAli Keshavarzian
Apr 26, 2001·The British Journal of Nutrition·W ScheppachT Menzel
Dec 1, 2002·Nutrition Research Reviews·Angel Gil, Ricardo Rueda
Jun 19, 2002·The Proceedings of the Nutrition Society·M C AldhousS Ghosh
Jul 31, 2001·Journal of Clinical Pathology·N P WoodcockJ MacFie
Dec 20, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Junqiang TianThomas R Ziegler
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·T Foitzik
Jan 18, 2005·The Journal of Surgical Research·Barbara E WildhaberDaniel H Teitelbaum
Jun 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F W GuglielmiA Francavilla
Jan 26, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Jing LiWei Cai
Nov 17, 2005·The British Journal of Surgery·J MacFieC J Mitchell
Apr 8, 2003·World Journal of Gastroenterology : WJG·Qing-Gang Hu, Qi-Chang Zheng
Jul 19, 2002·Chest Surgery Clinics of North America·Katherine Trahan, Dennis C Gore

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