Elemental imbalances in the olfactory pathway in Alzheimer's disease

Journal of the Neurological Sciences
D L SamudralwarW R Markesbery

Abstract

Concentrations of 11 trace elements were determined in 56 control and 98 Alzheimer's disease (AD) olfactory bulb, olfactory tract, olfactory trigone, piriform cortex and amygdala specimens by instrumental neutron activation analysis. Iron and zinc were significantly elevated and bromine was significantly depleted in olfactory regions of AD patients, compared with normal age-matched control subjects. Elevated iron could possibly play a role in neuronal degeneration in AD by enhancing reactive free radical formation.

References

Mar 1, 1976·Brain : a Journal of Neurology·D R CrapperS Quittkat
Jul 1, 1992·Neurobiology of Aging·R G Struble, H B Clark
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D SmithW R Markesbery
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C N OliverR A Floyd
Jan 1, 1990·Acta Neuropathologica·I Grundke-IqbalJ G Joshi
Nov 30, 1990·Science·P BrennanE B Keverne
Jul 1, 1990·Journal of Neurochemistry·K V SubbaraoL C Ang
Jan 1, 1989·Free Radical Research Communications·B Halliwell
Nov 1, 1985·Archives of Neurology·Z S Khachaturian
Feb 1, 1989·Journal of Neurochemistry·D T DexterC D Marsden
Jan 1, 1988·Mechanisms of Ageing and Development·D M MannP O Yates
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J Fleming, J G Joshi
Jun 1, 1987·Archives of Neurology·P F ReyesE Carner
Jan 1, 1987·Acta Neuropathologica·T G Ohm, H Braak
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C PearsonT P Powell
Nov 19, 1983·Lancet·P Averback
Oct 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·J SimpsonD M St Clair
Jan 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·M M Esiri, G K Wilcock
Jan 1, 1984·Neurobiology of Aging·W R MarkesberyT I Hossain
May 1, 1994·Trends in Neurosciences·J L Cadet
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Jan 1, 1993·Annals of Neurology·M A LovellW R Markesbery
Jul 1, 1993·Neurobiology of Aging·D C DaviesD A Lewis
Aug 1, 1987·Biological Trace Element Research·W D EhmannC M Thompson
Aug 1, 1987·Biological Trace Element Research·S S KrishnanD R McLachlan

❮ Previous
Next ❯

Citations

Jun 18, 1998·Biological Trace Element Research·C R CornettW R Markesbery
Mar 11, 2006·Cell Biology and Toxicology·M Omer BostanciSinan Canan
Oct 30, 2007·Cellular and Molecular Neurobiology·M Omer Bostanci, Faruk Bağirici
Oct 3, 2009·Cellular and Molecular Neurobiology·M Omer BostanciFaruk Bagirici
Jun 2, 2005·Progress in Neurobiology·Eugenio MocchegianiMarco Malavolta
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Dec 31, 2002·Brain Research. Brain Research Reviews·Math P Cuajungco, Kyle Y Fagét
Apr 1, 1997·Brain Research. Brain Research Reviews·M P Cuajungco, G J Lees
Dec 9, 1997·Neurobiology of Aging·M A LovellW R Markesbery
Jul 27, 2001·Brain Research Bulletin·D StrausakG Multhaup
Jun 28, 2002·Free Radical Biology & Medicine·Gerd MulthaupThomas A Bayer
Jan 1, 1997·Free Radical Biology & Medicine·W R Markesbery
Jul 20, 2011·The British Journal of Nutrition·Martin Loef, Harald Walach
Sep 24, 2009·Chemical Reviews·Reagan McRaeChristoph J Fahrni
Jul 23, 2002·The Proceedings of the Nutrition Society·Michael GrundmanPatrick Delaney
Apr 8, 1998·Annual Review of Neuroscience·D W Choi, J Y Koh
Nov 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Amie L PhinneyDavid Westaway
Jun 29, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Matthew SchragWolff Kirsch
Jun 15, 2006·Journal of Neuropathology and Experimental Neurology·Mark A LovellWilliam R Markesbery
Oct 31, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Scott AytonAshley I Bush
Jun 3, 2016·Frontiers in Neuroscience·Mercedes UnzetaJosé Marco-Contelles
Jan 1, 1999·Nutritional Neuroscience·M P CuajungcoA I Bush
Jul 22, 2008·Brain Research Bulletin·Li-Hong ZhangZhan-You Wang
Nov 21, 2007·Neurotoxicology·M Omer Bostanci, Faruk Bağirici
Nov 13, 2012·Free Radical Biology & Medicine·Scott AytonAshley I Bush
May 16, 2012·Nutritional Neuroscience·Martin LoefHarald Walach
Mar 29, 2014·Metallomics : Integrated Biometal Science·Alan RembachBlaine R Roberts
Dec 1, 2017·Nutrients·Inga WesselsLothar Rink
May 25, 2005·International Journal of Experimental Pathology·Christa J MaynardQiao-Xin Li
Jul 23, 2009·Synapse·Byron K Y Bitanihirwe, Miles G Cunningham
Jun 18, 2010·CNS Neuroscience & Therapeutics·Bogdan Florin Gh Popescu, Helen Nichol
May 7, 2015·Chembiochem : a European Journal of Chemical Biology·Rohan YadavRaghavendra Kikkeri
Sep 7, 2002·The Journal of Biological Chemistry·Christa J MaynardQiao-Xin Li
Jun 27, 2020·JAD Reports·Karissa BarthelsonMichael Lardelli
Sep 2, 2018·Biological Trace Element Research·Seshadri Reddy VarikasuvuMunikumar Manne
Mar 17, 2019·Journal of Molecular Neuroscience : MN·Geir BjørklundJan Aaseth
Mar 19, 2016·ChemMedChem·Raghavendra Vasudeva MurthyRaghavendra Kikkeri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.