PMID: 140655Mar 1, 1977

Elementary events in excitation-contraction coupling of the mammalian myocardium

Basic Research in Cardiology
H Antoni

Abstract

Excitation-contraction coupling of the mammalian myocardium is widely assumed to comprise the following chain of events: (1) Influx of Ca++ into the cell during the plateau phase of the action potential as well as Ca++ release from the subsarcolemmal cisternae of sarcoplasmic reticulum. (2) Activation of the contractile proteins by interaction of Ca++ with the troponin-tropomyosin system. (3) Relaxation due to reuptake of Ca++ by the sarcotubular system as well as by pumping of Ca++ out of the cell through the surface membrane and the transverse tubular system. (4) Movement of Ca++ in the longitudinal tubules back to the subsarcolemmal cisternae. A short comment is included about the effects of hypertrophy on the excitatory processes as well as on cellular structural constituents directly involved in excitation-contraction coupling.

References

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Citations

Mar 1, 1975·Journal of Molecular and Cellular Cardiology·H TritthartR Kaufmann
Sep 1, 1961·Journal de chirurgie·S EBASHI

Related Concepts

Myocardial Contraction
Troponin
Cardiac Hypertrophy
Calcium
Hypertrophy
Sarcoplasmic Reticulum
Cardiac Conduction System
Miniparamyosin
Nerve Impulses
TPM1

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