Elements in the canine distemper virus M 3' UTR contribute to control of replication efficiency and virulence.

PloS One
Danielle E AndersonVeronika von Messling

Abstract

Canine distemper virus (CDV) is a negative-sense, single-stranded RNA virus within the genus Morbillivirus and the family Paramyxoviridae. The Morbillivirus genome is composed of six transcriptional units that are separated by untranslated regions (UTRs), which are relatively uniform in length, with the exception of the UTR between the matrix (M) and fusion (F) genes. This UTR is at least three times longer and in the case of CDV also highly variable. Exchange of the M-F region between different CDV strains did not affect virulence or disease phenotype, demonstrating that this region is functionally interchangeable. Viruses carrying the deletions in the M 3' UTR replicated more efficiently, which correlated with a reduction of virulence, suggesting that overall length as well as specific sequence motifs distributed throughout the region contribute to virulence.

References

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Nov 12, 2003·Journal of Virology·Veronika von MesslingRoberto Cattaneo
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Sep 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Veronika von MesslingRoberto Cattaneo
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Citations

Apr 22, 2014·PloS One·Bettina BankampPaul A Rota
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Benjamin M Althouse, Kathryn A Hanley
Mar 9, 2019·Virology Journal·Santiago Rendon-MarinJulian Ruiz-Saenz
Jun 25, 2016·PLoS Neglected Tropical Diseases·Bronwyn A ClaytonGlenn A Marsh

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Datasets Mentioned

BETA
AF026234

Methods Mentioned

BETA
PCR
FCS
electrophoresis
light microscopy
in vitro transcription

Software Mentioned

MFOLD
Molecular Imaging
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