Elements of a unifying theory of biology

Acta Biotheoretica
V NorrisP Freestone

Abstract

To discover a unifying theory of biology, it is necessary first to believe in its existence and second to seek its elements. Such a theory would explain the regulation of the cell cycle, differentiation and the origin of life. Some elements of the theory may be obtained by considering both eukaryotic and prokaryotic cell cycles. These elements include cytoskeletal proteins, calcium, cyclins, protein kinase C, phosphorylation, transcriptional sensing, autocatalytic gene expression and the physical properties of lipids. Other more exotic candidate elements include the dynamic enzoskeleton, ATP generation, mechanotransduction, the piezoelectric effect and resonance. Bringing these disparate elements together--and discovering others--will require extensive collaborations between specialists from different sciences. This can only be achieved within the context of an integrated approach to biology.

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J J Tyson
Apr 1, 1991·Molecular Microbiology·V NorrisI B Holland
Feb 1, 1991·Research in Microbiology·S HiragaA Jaffé
Aug 7, 1987·Journal of Theoretical Biology·H R Leuchtag
Jul 10, 1989·Journal of Theoretical Biology·V Norris
Sep 1, 1986·European Journal of Biochemistry·J C CortayA J Cozzone
May 1, 1982·Journal of Bacteriology·G ChurchwardR Young
Apr 1, 1993·Trends in Neurosciences·R H ScottA C Dolphin
Feb 1, 1995·Molecular Microbiology·V Norris
Oct 1, 1994·Cell Calcium·P K Hepler
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·W Xia, W Dowhan
Sep 6, 1994·Chemistry and Physics of Lipids·J F TocanneM Welby
May 21, 1994·Journal of Theoretical Biology·V NorrisE Crooke
Jan 1, 1995·Advances in Microbial Physiology·R J Smith
Jan 1, 1996·Molecular Microbiology·V NorrisD Sigee
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·J MONOD, F JACOB

❮ Previous
Next ❯

Citations

Jul 22, 2004·Neurological Research·José A CabranesAna Barabash
Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.