Elephant pituitary gonadotropins

General and Comparative Endocrinology
J R McFarlaneH Papkoff

Abstract

We describe for the first time the purification and some properties of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) isolated from anterior pituitary tissue of the African elephant (Loxodonta africana). Methodology previously applied to equine and donkey pituitaries was used to obtain purified preparations of elephant LH and FSH in yields of 8.8 and 0.48 mg, respectively, per 10 g pituitary powder. The preparations were characterized by HPLC gel filtration and amino acid analysis, both of which showed the elephant LH and FSH to be very similar to ovine LH and FSH. The preparations were also characterized by radioimmunoassays and bioassays for LH and FSH and a radioreceptor assay for FSH. Results showed virtually no cross-contamination of hormonal activities in the elephant LH and FSH preparations. Elephant LH potencies ranged from 50 to 66% of highly purified ovine LH and elephant FSH potencies ranged from 21 to 52% of highly purified ovine FSH in the various assays employed. No evidence was found for any demonstrable intrinsic FSH activity in elephant LH. The assays employed suggest possible usage for making physiological measurements of gonadotropins in the elephant.

References

Mar 1, 1975·Archives of Biochemistry and Biophysics·J Ramachandran, M R Sairam
Dec 1, 1978·General and Comparative Endocrinology·P Licht, A B Gallo
Aug 1, 1975·Endocrinology·E D PlotkaG C Schmoller
Apr 1, 1972·Journal of Reproduction and Fertility·J Hanks, R V Short
Sep 1, 1981·The Biochemical Journal·M R Sairam
Jan 1, 1983·Journal of Reproduction and Fertility·J K HodgesA S McNeilly
May 1, 1983·Biology of Reproduction·D L HessM J Schmidt

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