Eleutherinone, a novel fungitoxic naphthoquinone from Eleutherine bulbosa (Iridaceae)

Memórias do Instituto Oswaldo Cruz
Tânia Maria Almeida AlvesC L Zani

Abstract

The dichloromethane extract prepared from the underground parts of Eleutherine bulbosa (Miller) Urban (Iridaceae) showed strong activity in the direct bioautography assay with the phytopathogenic fungus Cladosporium sphaerospermum. This assay was used to guide the fractionation of this extract and allowed the isolation of four compounds: the new naphthoquinone eleutherinone[8-methoxy-1-methyl-1,3-dihydro-naphtho(2,3-c)furan-4,9 -dione] and the known compounds, previously isolated from this species, eleutherin [9-methoxy-1(R),3(S)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], isoeleutherin [9-methoxy-1(R),3(R)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], and eleutherol [4-hydroxy-5-methoxy-3(R)-methyl-3H-naphtho(2,3-c)furan-1 -one]. All quinonoid compounds showed strong antifungal activity in the bioautography assay at 100 g/spot, while eleutherol was inactive.

References

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Sep 20, 2001·Memórias do Instituto Oswaldo Cruz·T M de Almeida AlvesC L Zani
Dec 18, 2001·Journal of Ethnopharmacology·J LinT P Mvelase

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Citations

Sep 14, 2010·Natural Product Research·Francesca R GalloMarcello Nicoletti
Apr 25, 2012·Canadian Journal of Microbiology·Erick Francisco RakotonirianaJoëlle Quetin-Leclercq
May 20, 2008·Journal of Pharmaceutical and Biomedical Analysis·Sompol ParamapojnHermann Stuppner
Dec 10, 2008·Chemistry, an Asian Journal·Xiaofan LiMasami Ishibashi
Oct 16, 2015·Pharmaceutical Biology·Adriana CamposValdir Cechinel Filho
Apr 26, 2008·Biochemical and Biophysical Research Communications·Jeong-Ho HongEun Sook Hwang
Aug 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·De-Li ChenGuo-Xu Ma
Jul 3, 2021·International Journal of Molecular Sciences·Ammar Akram KamarudinNorhaizan Mohd Esa
Aug 18, 2021·Toxicology Reports·Antonio Rafael Quadros GomesMaria Fâni Dolabela

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.