Elevated [(18)F]FDOPA utilization in the periaqueductal gray and medial nucleus accumbens of patients with early Parkinson's disease

NeuroImage
Yoshitaka KumakuraPaul Cumming

Abstract

PET studies with the DOPA decarboxylase substrate 6-[(18)F]fluoro-l-DOPA (FDOPA) reveal the storage of [(18)F]-fluorodopamine within synaptic vesicles, mainly of dopamine fibres. As such, FDOPA PET is a sensitive indicator of the integrity of the nigrostriatal dopamine innervation. Nonetheless, there have been several reports of focal elevations of FDOPA utilization in brain of patients with Parkinson's disease (PD), all based on reference tissue methods. To investigate this phenomenon further, we used voxel-wise steady-state kinetic analysis to search for regions of elevated FDOPA utilization (K; ml g(-1) min(-1)) and steady-state trapping (V(d); ml g(-1)) in a group of well-characterized patients with early, asymmetric PD, who were contrasted with an age-matched control group. Subtraction of the population mean parametric maps revealed foci of increased FDOPA utilization K (+25%) in the bilateral medial nucleus accumbens, whereas the expected declines in the trapping of FDOPA were seen in the caudate and putamen. This observation suggests hyperfunction of catecholamine fibres innervating specifically the limbic striatum, which could guide the design of future prospective FDOPA-PET studies of the impulse control disorders occu...Continue Reading

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Citations

Jun 20, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Jan KalbitzerMichael A Rapp
Dec 27, 2011·NeuroImage·Clas LinnmanDavid Borsook
Sep 18, 2010·British Journal of Pharmacology·Paul CummingJeffrey W Dalley
Apr 1, 2015·Parkinsonism & Related Disorders·Jianli WangThyagarajan Subramanian
Oct 31, 2019·Brain : a Journal of Neurology·Philip E MosleyAlistair Perry
Aug 9, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Michael WalkerKristina Herfert
Oct 23, 2019·Frontiers in Aging Neuroscience·Xiaojuan DanPiu Chan
May 10, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lionel C LibertChristian F Lemaire

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